Chlorobenzene

Chlorobenzene

SCHEMBL6154007

Clc1ccccc1.O=C1Cc2ccccc2CO1

nearest known ligand 0.42

Full drug profile on Sugi Atlas →

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MAOB P27338 6/20 0.42
MAOA P21397 4/20 0.42
TSHR P16473 1/20 0.41
CYP1A2 P05177 2/20 0.40
KDM4E B2RXH2 1/20 0.37
ALDH1A1 P00352 1/20 0.37
TYMS P04818 1/20 0.37
HPGD P15428 1/20 0.37
CYP2C19 P33261 1/20 0.37
HSD17B10 Q99714 1/20 0.37
POLB P06746 1/20 0.37
KMT2A Q03164 1/20 0.36
CYP2A6 P11509 1/20 0.35
CASP6 P55212 1/20 0.33
SIGMAR1 Q99720 1/20 0.33
NOTUM Q6P988 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL724064 0.88 MAOA (0.52) MAOBMAOACYP1A2KDM4EALDH1A1
SCHEMBL29736194 0.82 MAOA (0.54) MAOBMAOACYP1A2KDM4EALDH1A1
SCHEMBL28603304 0.70 MAOA (0.68) MAOBMAOACYP1A2KDM4EALDH1A1
SCHEMBL29072819 0.70 CYP1A2 (0.48) MAOBMAOATSHRCYP1A2KDM4E
SCHEMBL29467263 0.70 MAOA (0.50) MAOBMAOATSHRCYP1A2KDM4E
SCHEMBL29477917 0.68 MAOA (0.48) MAOBMAOATSHRCYP1A2KDM4E
SCHEMBL6136225 0.68 CYP1A2 (0.57) MAOBMAOACYP1A2CYP2A6
SCHEMBL11205483 0.68 MAOA (0.58) MAOBMAOATSHRCYP1A2KDM4E
SCHEMBL13760592 0.68 ALDH1A1 (0.42) MAOBMAOAALDH1A1
SCHEMBL18589786 0.68 ALDH1A1 (0.42) MAOBMAOAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1506184-A2 PROCESS FOR THE PREPARATION OF 3-ISOCHROMANONE Syngenta Limited (GB) 2005-02-16 EP disclosed
WO-2003095442-A2 PROCESS FOR THE PREPARATION OF 3-ISOCHROMANONE SYNGENTA LIMITED (GB) 2003-11-20 WO disclosed