Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.69 |
| ▸ | MEN1 | O00255 | 1/20 | 0.69 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.69 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | USP2 | O75604 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12939705 | 0.86 | POLB (0.74) | POLBKDM4EALDH1A1MAPK1KMT2A | |
| SCHEMBL12793323 | 0.85 | KDM4E (0.79) | POLBKDM4EALDH1A1MAPK1KMT2A | |
| SCHEMBL4009309 | 0.84 | KDM4E (0.77) | POLBKDM4EALDH1A1MAPK1KMT2A | |
| SCHEMBL2080837 | 0.84 | KDM4E (0.77) | POLBKDM4EALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL2831202 | 0.84 | KDM4E (0.77) | POLBKDM4EALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL5306415 | 0.84 | POLB (1.00) | POLBKDM4EALDH1A1KMT2APKM | |
| SCHEMBL12386397 | 0.84 | KDM4E (0.77) | POLBKDM4EALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL4008490 | 0.83 | POLB (0.71) | POLBKDM4EALDH1A1MAPK1KMT2A | |
| SCHEMBL13182556 | 0.81 | POLB (0.68) | POLBKDM4EALDH1A1MAPK1KMT2A | |
| SCHEMBL12386392 | 0.80 | KDM4E (0.71) | POLBKDM4EALDH1A1MAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050182040-A1 | Benzamide derivatives | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2005-08-18 | — | — | US | disclosed |
| EP-1500643-A1 | BENZAMIDE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2005-01-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050182040-A1 | Benzamide derivatives | ROCK1, ROCK2, NHERF1 | POLB 4155/4885KDM4E 2017/4885ALDH1A1 2454/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.