Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MELK | Q14680 | 2/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | PRKD1 | Q15139 | 4/20 | 0.36 |
| ▸ | PRKD2 | Q9BZL6 | 4/20 | 0.36 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 2/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6154506 | 0.76 | ROCK2 (0.47) | IRAK4BRD4ATAD2ROCK2CDK5 | |
| SCHEMBL6154711 | 0.76 | TOP2A (0.47) | IRAK4BRD4ATAD2P2RX7AURKA | |
| SCHEMBL6154956 | 0.74 | ROCK2 (0.58) | MELKROCK2P2RX7HTR4AURKA | |
| SCHEMBL6154636 | 0.72 | TOP2A (0.46) | PRKD1PRKD2CHEK1 | |
| SCHEMBL6153331 | 0.71 | ROCK2 (0.40) | ROCK2CDK5CDK5R1AURKARPS6KB1 | |
| SCHEMBL27644625 | 0.70 | KDM1A (0.40) | CDK5CDK5R1 | |
| SCHEMBL6154865 | 0.70 | ROCK2 (0.72) | ROCK2CDK5CDK5R1AURKARPS6KB1 | |
| SCHEMBL6156929 | 0.68 | MAPK14 (0.47) | PRKD1PRKD2RPS6KB1CHEK1 | |
| SCHEMBL4144350 | 0.68 | IRAK4 (0.45) | IRAK4BRD4ATAD2P2RX7AURKA | |
| SCHEMBL17699912 | 0.68 | BTK (0.71) | BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050182040-A1 | Benzamide derivatives | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2005-08-18 | — | — | US | disclosed |
| EP-1500643-A1 | BENZAMIDE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2005-01-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050182040-A1 | Benzamide derivatives | ROCK1, ROCK2, NHERF1 | MELK 2442/4885IRAK4 3240/4885BRD4 865/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.