Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | MAPT | P10636 | 6/20 | 0.55 |
| ▸ | OGG1 | O15527 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | MPO | P05164 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | KDM5A | P29375 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6154794 | 0.85 | MAPT (0.57) | KDM4EALDH1A1MAPTOGG1LMNA | |
| SCHEMBL1202191 | 0.82 | HPGD (0.62) | KDM4EALDH1A1MAPTLMNAL3MBTL1 | |
| SCHEMBL29994706 | 0.82 | HPGD (0.62) | KDM4EALDH1A1MAPTLMNAL3MBTL1 | |
| SCHEMBL4176796 | 0.81 | HDAC8 (0.52) | KDM4EALDH1A1MAPTMAOBCA2 | |
| Hydrochloric Acid SCHEMBL155794 | 0.81 | HPGD (0.61) | KDM4EALDH1A1MAPTLMNAL3MBTL1 | |
| SCHEMBL13568210 | 0.81 | HPGD (0.45) | KDM4EALDH1A1MAPTL3MBTL1MAOB | |
| SCHEMBL13753912 | 0.81 | HPGD (0.50) | KDM4EALDH1A1MAPTLMNAL3MBTL1 | |
| SCHEMBL21638086 | 0.79 | OGG1 (0.57) | KDM4EALDH1A1MAPTOGG1LMNA | |
| SCHEMBL30015840 | 0.79 | OGG1 (0.57) | KDM4EALDH1A1MAPTOGG1LMNA | |
| SCHEMBL2648578 | 0.79 | OGG1 (0.57) | KDM4EALDH1A1MAPTOGG1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250206724-A1 | SUBSTITUTED 3-AMINO INDAZOLE DERIVATIVES AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2025-06-26 | — | — | US | disclosed |
| EP-4499612-A1 | SUBSTITUTED 3-AMINO INDAZOLE DERIVATIVES AS KINASE INHIBITORS | Nerviano Medical Sciences S.r.l. (IT) | 2025-02-05 | — | — | EP | disclosed |
| CN-118974020-A | Substituted 3-aminoindazole derivatives as kinase inhibitors | 内尔维亚诺医疗科学公司 | 2024-11-15 | — | — | CN | disclosed |
| WO-2023186773-A1 | SUBSTITUTED 3-AMINO INDAZOLE DERIVATIVES AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2023-10-05 | — | — | WO | disclosed |
| EP-2744330-B1 | SUBSTITUTED (E)-N'-(1-PHENYLETHYLIDENE) BENZOHYDRAZIDE ANALOGS AS HISTONE DEMETHYLASE INHIITORS | UNIV UTAH RES FOUND (US) | 2020-07-15 | — | — | EP | disclosed |
| EP-2744330-B1 | SUBSTITUTED (E)-N'-(1-PHENYLETHYLIDENE) BENZOHYDRAZIDE ANALOGS AS HISTONE DEMETHYLASE INHIITORS | UNIV UTAH RES FOUND (US) | 2020-07-15 | — | — | EP | disclosed |
| EP-3010915-B1 | SUBSTITUTED (3-(5-CHLORO-2-HYDROXYPHENYL)-1-BENZOYL-1H-PYRAZOLE COMPOUNDS AS HISTONE DEMETHYLASE INHIBITORS | UNIV UTAH RES FOUND (US) | 2019-05-08 | — | — | EP | disclosed |
| EP-3010915-B1 | SUBSTITUTED (3-(5-CHLORO-2-HYDROXYPHENYL)-1-BENZOYL-1H-PYRAZOLE COMPOUNDS AS HISTONE DEMETHYLASE INHIBITORS | UNIV UTAH RES FOUND (US) | 2019-05-08 | — | — | EP | disclosed |
| WO-2018224455-A1 | SUBSTITUTED CYCLOPROPYL DERIVATIVES | BASF SE (DE) | 2018-12-13 | — | — | WO | disclosed |
| US-9642857-B2 | Substituted (E)-N′-(1-phenylethylidene)benzohydrazide analogs as histone demethylase inhibitors | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2017-05-09 | — | — | US | disclosed |
| WO-2014205213-A1 | SUBSTITUTED (E)-N'-(1-PHENYLETHYLIDENE) BENZOHYDRAZIDE ANALOGS AS HISTONE DEMETHYLASE INHIBITORS | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2014-12-24 | — | — | WO | disclosed |
| EP-2744330-A1 | SUBSTITUTED (E)-N'-(1-PHENYLETHYLIDENE) BENZOHYDRAZIDE ANALOGS AS HISTONE DEMETHYLASE INHIITORS | University Of Utah Research Foundation (US) | 2014-06-25 | — | — | EP | disclosed |
| US-20140163017-A1 | SUBSTITUTED (E)-N'-(1-PHENYLETHYLIDENE)BENZOHYDRAZIDE ANALOGS AS HISTONE DEMETHYLASE INHIBITORS | UNIVERSITY OF UTAH (US) | 2014-06-12 | — | — | US | disclosed |
| US-20140163017-A1 | SUBSTITUTED (E)-N'-(1-PHENYLETHYLIDENE)BENZOHYDRAZIDE ANALOGS AS HISTONE DEMETHYLASE INHIBITORS | UNIVERSITY OF UTAH (US) | 2014-06-12 | — | — | US | disclosed |
| US-20140163017-A1 | SUBSTITUTED (E)-N'-(1-PHENYLETHYLIDENE)BENZOHYDRAZIDE ANALOGS AS HISTONE DEMETHYLASE INHIBITORS | UNIVERSITY OF UTAH (US) | 2014-06-12 | — | — | US | disclosed |
| WO-2013025805-A1 | SUBSTITUTED (E)-N'-(1-PHENYLETHYLIDENE) BENZOHYDRAZIDE ANALOGS AS HISTONE DEMETHYLASE INHIITORS | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2013-02-21 | — | — | WO | disclosed |
| WO-2013025805-A1 | SUBSTITUTED (E)-N'-(1-PHENYLETHYLIDENE) BENZOHYDRAZIDE ANALOGS AS HISTONE DEMETHYLASE INHIITORS | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2013-02-21 | — | — | WO | disclosed |
| US-20050065118-A1 | Organosulfur inhibitors of tyrosine phosphatases | METABASIS THERAPEUTICS, INC. | 2005-03-24 | — | — | US | disclosed |
| EP-1446110-A2 | ORGANOSULFUR INHIBITORS OF TYROSINE PHOSPHATASES | Structural Bioinformatics Inc. (US) | 2004-08-18 | — | — | EP | disclosed |
| WO-2003032916-A2 | ORGANOSULFUR INHIBITORS OF TYROSINE PHOSPHATASES | STRUCTURAL BIOINFORMATICS INC. (US) | 2003-04-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250206724-A1 | SUBSTITUTED 3-AMINO INDAZOLE DERIVATIVES AS KINASE INHIBITORS | CDK1, CDK11A, CDK3 | KDM4E 1212/4885ALDH1A1 4385/4885MAPT 2277/4885 |
| US-20140163017-A1 | SUBSTITUTED (E)-N'-(1-PHENYLETHYLIDENE)BENZOHYDRAZIDE ANALOGS AS HISTONE DEMETHYLASE INHIBITORS | KDM1B, KDM1A, DOT1L | KDM4E 5/4885ALDH1A1 587/4885MAPT 1088/4885 |
| US-20050065118-A1 | Organosulfur inhibitors of tyrosine phosphatases | PTPRS, PTPRJ, PTPRCAP | KDM4E 1133/4885ALDH1A1 961/4885MAPT 3318/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.