Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | GSK3B | P49841 | 1/20 | 0.51 |
| ▸ | MITF | O75030 | 1/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.49 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.48 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.48 |
| ▸ | FABP1 | P07148 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.47 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.47 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5558657 | 0.88 | NPC1 (0.53) | NPC1RAB9AAKR1C3AKR1C2DYRK1A | |
| SCHEMBL6153554 | 0.86 | AKR1C3 (0.47) | AKR1C3AKR1C2ROCK2ROCK1KDM4E | |
| SCHEMBL5556608 | 0.81 | ROCK2 (0.50) | NPC1RAB9AAKR1C3AKR1C2ROCK2 | |
| SCHEMBL5556693 | 0.81 | ROCK1 (0.49) | NPC1RAB9AGSK3BDYRK1AROCK2 | |
| SCHEMBL6154251 | 0.79 | NR1H4 (0.54) | NPC1RAB9AROCK2ROCK1MEN1 | |
| SCHEMBL6153810 | 0.78 | KMO (0.55) | NPC1RAB9AAKR1C3ROCK2ROCK1 | |
| SCHEMBL5464421 | 0.75 | NPC1 (0.78) | NPC1RAB9AGSK3BMITFAKR1C3 | |
| SCHEMBL6244318 | 0.74 | SMN1; SMN2 (0.47) | NPC1RAB9ADYRK1AROCK1CSNK2A1 | |
| SCHEMBL5556610 | 0.74 | AKR1C3 (0.44) | NPC1RAB9AAKR1C3AKR1C2ROCK2 | |
| SCHEMBL2867923 | 0.74 | AKR1C3 (0.73) | NPC1RAB9AMITFAKR1C3FABP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050065118-A1 | Organosulfur inhibitors of tyrosine phosphatases | METABASIS THERAPEUTICS, INC. | 2005-03-24 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050065118-A1 | Organosulfur inhibitors of tyrosine phosphatases | PTPRS, PTPRJ, PTPRCAP | NPC1 4548/4885RAB9A 3814/4885GSK3B 3097/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.