Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 14/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 12/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 6/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6157219 | 0.88 | PTGS2 (0.42) | PTGS2PTGS1ALOX5 | |
| SCHEMBL6158740 | 0.86 | PTGS2 (0.38) | PTGS2PTGS1ALOX5 | |
| SCHEMBL6156608 | 0.75 | PTGS2 (0.32) | PTGS2PTGS1ALOX5 | |
| SCHEMBL6154450 | 0.74 | SLC5A2 (0.36) | PTGS2PTGS1ALOX5 | |
| SCHEMBL6154355 | 0.74 | PTGS2 (0.35) | PTGS2PTGS1ALOX5 | |
| SCHEMBL6154685 | 0.74 | PTGS2 (0.42) | PTGS2PTGS1ALOX5 | |
| SCHEMBL6158924 | 0.74 | PTGS2 (0.32) | PTGS2PTGS1ALOX5 | |
| SCHEMBL6875997 | 0.74 | PTGS2 (0.32) | PTGS2PTGS1ALOX5 | |
| SCHEMBL6153090 | 0.72 | PTGS2 (0.48) | PTGS2PTGS1ALOX5 | |
| SCHEMBL6758647 | 0.72 | PTGS1 (0.32) | PTGS2PTGS1ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499578-A2 | PRIME RING SUBSTITUTED THYROID RECEPTOR ANTAGONISTS FOR THE TREATMENT OF CARDIAC AND METABOLIC DISORDERS | KARO BIO AB (SE) | 2005-01-26 | — | — | EP | disclosed |
| WO-2003018515-A2 | PRIME RING SUBSTITUTED THYROID RECEPTOR ANTAGONISTS FOR THE TREATMENT OF CARDIAC AND METABOLIC DISORDERS | KARO BIO AB (SE) | 2003-03-06 | — | — | WO | disclosed |