Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 18/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 16/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 9/20 | 0.40 |
| ▸ | RARB | P10826 | 2/20 | 0.36 |
| ▸ | RARG | P13631 | 2/20 | 0.36 |
| ▸ | RARA | P10276 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6757717 | 0.87 | PTGS2 (0.47) | PTGS2PTGS1ALOX5RARBRARG | |
| SCHEMBL6757720 | 0.87 | PTGS2 (0.47) | PTGS2PTGS1ALOX5RARBRARG | |
| SCHEMBL6756525 | 0.85 | PTGS2 (0.43) | PTGS2PTGS1ALOX5RARBRARG | |
| SCHEMBL6755894 | 0.84 | PTGS2 (0.41) | PTGS2PTGS1ALOX5RARBRARG | |
| SCHEMBL6755222 | 0.76 | PTGS2 (0.41) | PTGS2PTGS1ALOX5RARBRARG | |
| SCHEMBL6756543 | 0.74 | PTGS2 (0.40) | PTGS2PTGS1ALOX5RARBRARG | |
| SCHEMBL6154526 | 0.74 | PTGS2 (0.37) | PTGS2PTGS1ALOX5 | |
| SCHEMBL6757715 | 0.73 | PTGS1 (0.40) | PTGS2PTGS1ALOX5RARBRARG | |
| SCHEMBL6756521 | 0.73 | PTGS2 (0.39) | PTGS2PTGS1ALOX5RARBRARG | |
| SCHEMBL6756599 | 0.71 | PTGS2 (0.38) | PTGS2PTGS1ALOX5RARBRARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499604-A1 | DIHYDROBENZOFURAN AND DIHYDROBENZOTHIOPHENE 2,4-PENTAIDENOIC ACID DERIVATIVES HAVING SELECTIVE ACTIVITY FOR RETINOID X (RXR) RECEPTORS | Allergan, Inc. (US) | 2005-01-26 | — | — | EP | disclosed |
| WO-2003093257-A1 | DIHYDROBENZOFURAN AND DIHYDROBENZOTHIOPHENE 2,4-PENTAIDENOIC ACID DERIVATIVES HAVING SELECTIVE ACTIVITY FOR RETINOID X (RXR) RECEPTORS | ALLERGAN, INC. (US) | 2003-11-13 | — | — | WO | disclosed |