Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | MLYCD | O95822 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2117865 | 0.85 | KDM4E (0.52) | KDM4EMAPTMEN1KMT2AHSP90AA1 | |
| SCHEMBL10147459 | 0.85 | ALPL (0.44) | KDM4EMAPTMEN1KMT2AL3MBTL1 | |
| SCHEMBL2299722 | 0.84 | LMNA (0.48) | MAPTMEN1KMT2AL3MBTL1MAOB | |
| SCHEMBL19814488 | 0.78 | MAPT (0.49) | MAPTMEN1KMT2AHPGD | |
| SCHEMBL29775670 | 0.78 | MAPT (0.49) | MAPTMEN1KMT2AHPGD | |
| SCHEMBL31124009 | 0.76 | GAA (0.41) | KDM4EMAPTMEN1KMT2AHDAC4 | |
| SCHEMBL2300298 | 0.76 | LMNA (0.44) | MAPTMEN1KMT2AHDAC4HDAC6 | |
| SCHEMBL21317626 | 0.74 | POLB (0.45) | KDM4EMAPTMEN1KMT2AHDAC4 | |
| SCHEMBL19766782 | 0.74 | HSP90AA1 (0.38) | KDM4EMAPTHSP90AA1L3MBTL1ALDH1A1 | |
| SCHEMBL7669777 | 0.74 | CYP1A2 (0.44) | KDM4EMAPTL3MBTL1ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1585733-A1 | HETEROCYCLIC PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2005-10-19 | — | — | EP | disclosed |
| WO-2004063166-A1 | HETEROCYCLIC PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2004-07-29 | — | — | WO | disclosed |