Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | RECQL | P46063 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6153142 | 0.94 | CYP2C9 (0.37) | MEN1KMT2ACYP2C9CYP3A4ALDH1A1 | |
| SCHEMBL6153144 | 0.94 | PPARG (0.35) | MEN1KMT2AALDH1A1HPGDL3MBTL1 | |
| SCHEMBL7492036 | 0.90 | ALDH1A1 (0.40) | MEN1KMT2ACYP2C9CYP3A4ALDH1A1 | |
| SCHEMBL6154618 | 0.88 | KDM4E (0.36) | MEN1KMT2ACYP2C9CYP3A4ALDH1A1 | |
| SCHEMBL6945502 | 0.85 | HSD17B10 (0.36) | MEN1KMT2ACYP2C9CYP3A4ALDH1A1 | |
| SCHEMBL6940628 | 0.85 | CYP2C9 (0.36) | MEN1KMT2ACYP2C9CYP3A4ALDH1A1 | |
| SCHEMBL6153193 | 0.85 | LMNA (0.36) | MEN1KMT2ACYP2C9CYP3A4ALDH1A1 | |
| SCHEMBL7837790 | 0.84 | MEN1 (0.44) | MEN1KMT2ACYP2C9CYP3A4ALDH1A1 | |
| SCHEMBL7491122 | 0.83 | MEN1 (0.35) | MEN1KMT2ACYP2C9CYP3A4ALDH1A1 | |
| SCHEMBL6152458 | 0.83 | SLC6A4 (0.35) | MEN1KMT2ACYP2C9CYP3A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1307449-B1 | 1,4-DIHYDROPYRIDINES AS BRADYKININ ANTAGONISTS | PFIZER PHARMA (JP) | 2005-12-07 | — | — | EP | disclosed |
| EP-1307449-A1 | 1,4-DIHYDROPYRIDINES AS BRADYKININ ANTAGONISTS | PFIZER PHARMACEUTICALS INC. (JP) | 2003-05-07 | — | — | EP | disclosed |
| WO-2002012235-A1 | 1,4-DIHYDROPYRIDINES AS BRADYKININ ANTAGONISTS | PFIZER PHARMACEUTICALS INC. (JP) | 2002-02-14 | — | — | WO | disclosed |