Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 1/20 | 0.50 |
| ▸ | VDR | P11473 | 9/20 | 0.39 |
| ▸ | CYP24A1 | Q07973 | 2/20 | 0.39 |
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6156458 | 0.86 | HMGCR (0.40) | HMGCRVDRCYP24A1DHFRHSD11B1 | |
| SCHEMBL6158244 | 0.85 | PPARA (0.39) | DHFR | |
| SCHEMBL6886057 | 0.84 | CYP4F2 (0.39) | DHFRKDM4EALDH1A1HPGDHDAC4 | |
| SCHEMBL6878864 | 0.83 | HMGCR (0.35) | HMGCRDHFR | |
| SCHEMBL6160284 | 0.78 | HMGCR (0.32) | HMGCRDHFR | |
| SCHEMBL6155888 | 0.76 | HSP90AA1 (0.38) | HMGCRDHFRKDM4CKDM4EALDH1A1 | |
| SCHEMBL2106841 | 0.76 | HMGCR (0.56) | HMGCRVDRCYP24A1KDM4EALDH1A1 | |
| SCHEMBL6155055 | 0.76 | HMGCR (0.56) | HMGCRVDRCYP24A1KDM4EALDH1A1 | |
| SCHEMBL2106842 | 0.76 | HMGCR (0.56) | HMGCRVDRCYP24A1KDM4EALDH1A1 | |
| SCHEMBL6155060 | 0.76 | HMGCR (0.56) | HMGCRVDRCYP24A1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1124779-B1 | VITAMIN D ANALOGUES | GALDERMA RES & DEV (FR) | 2005-02-02 | — | — | EP | disclosed |
| US-6689922-B1 | BIAROMATIC COMPOUNDS WHICH ARE ANALOGUES OF VITAMIN D HAVE A MARKED ACTIVITY IN THE FIELDS OF CELL DIFFERENTIATION AND PROLIFERATION | GALDERMA RESEARCH & DEVELOPMENT S.N.C. (FR) | 2004-02-10 | — | — | US | disclosed |
| EP-1124779-A1 | VITAMIN D ANALOGUES | Galderma Research & Development, S.N.C. (FR) | 2001-08-22 | — | — | EP | disclosed |
| WO-2000026167-A1 | VITAMIN D ANALOGUES | GALDERMA RESEARCH & DEVELOPMENT, S.N.C. (FR) | 2000-05-11 | — | — | WO | disclosed |