Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | VDR | P11473 | 2/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | BCR | P11274 | 1/20 | 0.32 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.30 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6154774 | 0.86 | HMGCR (0.50) | HMGCRHSD11B1DHFRKDM4EALDH1A1 | |
| SCHEMBL6156493 | 0.85 | TBXAS1 (0.41) | HSD11B1MEN1KMT2A | |
| SCHEMBL6879375 | 0.84 | KDM4E (0.37) | HSD11B1KDM4EALDH1A1HPGDPTPN1 | |
| SCHEMBL2106706 | 0.75 | LCK (0.49) | HMGCRKDM4EALDH1A1HPGDABL1 | |
| SCHEMBL2106702 | 0.75 | LCK (0.49) | HMGCRKDM4EALDH1A1HPGDABL1 | |
| SCHEMBL2107065 | 0.72 | LCK (0.50) | HMGCRKDM4EALDH1A1HPGDABL1 | |
| SCHEMBL2107064 | 0.72 | LCK (0.50) | HMGCRKDM4EALDH1A1HPGDABL1 | |
| SCHEMBL6158244 | 0.70 | PPARA (0.39) | DHFRMEN1KMT2A | |
| SCHEMBL6886057 | 0.70 | CYP4F2 (0.39) | DHFRKDM4EALDH1A1HPGD | |
| SCHEMBL6156407 | 0.70 | KDM4E (0.40) | HMGCRKDM4EALDH1A1ABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1124779-B1 | VITAMIN D ANALOGUES | GALDERMA RES & DEV (FR) | 2005-02-02 | — | — | EP | disclosed |
| US-6689922-B1 | BIAROMATIC COMPOUNDS WHICH ARE ANALOGUES OF VITAMIN D HAVE A MARKED ACTIVITY IN THE FIELDS OF CELL DIFFERENTIATION AND PROLIFERATION | GALDERMA RESEARCH & DEVELOPMENT S.N.C. (FR) | 2004-02-10 | — | — | US | disclosed |
| EP-1124779-A1 | VITAMIN D ANALOGUES | Galderma Research & Development, S.N.C. (FR) | 2001-08-22 | — | — | EP | disclosed |
| WO-2000026167-A1 | VITAMIN D ANALOGUES | GALDERMA RESEARCH & DEVELOPMENT, S.N.C. (FR) | 2000-05-11 | — | — | WO | disclosed |