Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CDC25B | P30305 | 2/20 | 0.39 |
| ▸ | CDC25A | P30304 | 1/20 | 0.39 |
| ▸ | CDC25C | P30307 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | THPO | P40225 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | CBR1 | P16152 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28368241 | 0.82 | RAB9A (0.51) | RAB9AALDH1A1HPGDCDC25BCDC25A | |
| SCHEMBL6719963 | 0.82 | SIGMAR1 (0.45) | SIGMAR1TSHRTP53CYP2D6THPO | |
| Hydrochloric Acid SCHEMBL7411638 | 0.81 | SIGMAR1 (0.44) | SIGMAR1TSHRTP53CYP2D6THPO | |
| Aptiganel SCHEMBL29742194 | 0.79 | SIGMAR1 (0.62) | SIGMAR1ALDH1A1HPGDTSHRTP53 | |
| Aptiganel SCHEMBL151144 | 0.79 | SIGMAR1 (0.62) | SIGMAR1ALDH1A1HPGDTSHRTP53 | |
| Aptiganel SCHEMBL29430152 | 0.78 | SIGMAR1 (0.60) | SIGMAR1TSHRTP53CYP2D6THPO | |
| Aptiganel SCHEMBL871689 | 0.78 | SIGMAR1 (0.60) | SIGMAR1TSHRTP53CYP2D6THPO | |
| Aptiganel SCHEMBL7621534 | 0.76 | SIGMAR1 (0.58) | SIGMAR1TSHRTP53CYP2D6THPO | |
| SCHEMBL6154912 | 0.75 | SIGMAR1 (0.43) | SIGMAR1ALDH1A1TSHRTP53CYP2D6 | |
| SCHEMBL28373346 | 0.73 | RAB9A (0.43) | RAB9AALDH1A1HPGDCDC25BCDC25A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0940139-B1 | Substituted guanidines and derivatives thereof as modulators of neurotransmitter release and novel methodology for identifying neurotransmitter release blockers | SCION PHARMACEUTICALS INC (US) | 2005-02-02 | — | — | EP | disclosed |
| EP-0584088-B1 | SUBSTITUTED GUANIDINES AND DERIVATIVES THEREOF AS MODULATORS OF NEUROTRANSMITTER RELEASE AND NOVEL METHODOLOGY FOR IDENTIFYING NEUROTRANSMITTER RELEASE BLOCKERS | CAMBRIDGE NEUROSCIENCE RES (US) | 1999-10-27 | — | — | EP | disclosed |
| EP-0940139-A2 | Substituted guanidines and derivatives thereof as modulators of neurotransmitter release and novel methodology for identifying neurotransmitter release blockers | CAMBRIDGE NEUROSCIENCE RESEARCH, INC. (US) | 1999-09-08 | — | — | EP | disclosed |
| WO-1992014697-A1 | SUBSTITUTED GUANIDINES AND DERIVATIVES THEREOF AS MODULATORS OF NEUROTRANSMITTER RELEASE AND NOVEL METHODOLOGY FOR IDENTIFYING NEUROTRANSMITTER RELEASE BLOCKERS | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1992-09-03 | — | — | WO | disclosed |