Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | GUSB | P08236 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6153939 | 0.91 | GUSB (0.56) | ALDH1A1L3MBTL1GUSBTP53MAPT | |
| SCHEMBL6153628 | 0.80 | ROCK1 (0.53) | ALDH1A1ROCK1ROCK2GUSBKDM4E | |
| SCHEMBL6154672 | 0.78 | GUSB (0.61) | ALDH1A1ROCK1ROCK2GUSBTP53 | |
| SCHEMBL6690137 | 0.74 | GUSB (0.48) | ALDH1A1ROCK1ROCK2GUSBKDM4E | |
| SCHEMBL6155528 | 0.73 | GUSB (0.57) | ALDH1A1L3MBTL1ROCK1ROCK2GUSB | |
| SCHEMBL6155284 | 0.73 | GUSB (0.56) | ALDH1A1ROCK1ROCK2GUSBKDM4E | |
| SCHEMBL6154359 | 0.73 | GUSB (0.65) | ALDH1A1L3MBTL1ROCK1ROCK2GUSB | |
| SCHEMBL4954816 | 0.72 | GUSB (0.56) | ALDH1A1L3MBTL1ROCK1ROCK2GUSB | |
| SCHEMBL6153472 | 0.72 | GUSB (0.53) | ALDH1A1ROCK1ROCK2GUSBKDM4E | |
| SCHEMBL6153810 | 0.72 | KMO (0.55) | ALDH1A1ROCK1ROCK2GUSBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050065118-A1 | Organosulfur inhibitors of tyrosine phosphatases | METABASIS THERAPEUTICS, INC. | 2005-03-24 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050065118-A1 | Organosulfur inhibitors of tyrosine phosphatases | PTPRS, PTPRJ, PTPRCAP | ALDH1A1 961/4885L3MBTL1 279/4885ROCK1 3290/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.