SCHEMBL6690137

SCHEMBL6690137

Cc1ccc(Nc2nnc(-c3cccc(OCCO)c3)s2)cc1Cl

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GUSB P08236 1/20 0.48
ROCK1 Q13464 2/20 0.48
ROCK2 O75116 1/20 0.48
KDM4E B2RXH2 3/20 0.45
DHODH Q02127 3/20 0.45
ALDH1A1 P00352 2/20 0.44
HPGD P15428 2/20 0.44
HSD17B10 Q99714 2/20 0.44
MEN1 O00255 2/20 0.44
KMT2A Q03164 2/20 0.44
POLB P06746 1/20 0.44
CTDSP1 Q9GZU7 1/20 0.44
HDAC1 Q13547 7/20 0.44
HDAC2 Q92769 7/20 0.44
SMN1; SMN2 Q16637 3/20 0.44
HDAC8 Q9BY41 3/20 0.43
HDAC6 Q9UBN7 3/20 0.43
USP2 O75604 1/20 0.43
CCNC P24863 1/20 0.41
CDK8 P49336 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6153546 0.86 GUSB (0.49) GUSBROCK1ROCK2KDM4EDHODH
SCHEMBL6156436 0.82 GUSB (0.49) GUSBROCK1ROCK2KDM4EDHODH
SCHEMBL6154672 0.81 GUSB (0.61) GUSBROCK1ROCK2KDM4EDHODH
SCHEMBL6684447 0.79 GUSB (0.48) GUSBROCK1ROCK2KDM4EDHODH
SCHEMBL6153921 0.78 NOTUM (0.53) GUSBROCK1ROCK2KDM4EALDH1A1
SCHEMBL6154585 0.78 NOTUM (0.53) GUSBROCK1ROCK2KDM4EALDH1A1
SCHEMBL6153628 0.77 ROCK1 (0.53) GUSBROCK1ROCK2KDM4EDHODH
SCHEMBL6155284 0.75 GUSB (0.56) GUSBROCK1ROCK2KDM4EDHODH
SCHEMBL6155022 0.74 ALDH1A1 (0.49) GUSBROCK1ROCK2KDM4EALDH1A1
SCHEMBL6154575 0.74 GUSB (0.61) GUSBROCK1ROCK2KDM4EDHODH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1446110-A2 ORGANOSULFUR INHIBITORS OF TYROSINE PHOSPHATASES Structural Bioinformatics Inc. (US) 2004-08-18 EP disclosed
WO-2003032916-A2 ORGANOSULFUR INHIBITORS OF TYROSINE PHOSPHATASES STRUCTURAL BIOINFORMATICS INC. (US) 2003-04-24 WO disclosed