Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 4/20 | 0.40 |
| ▸ | CA1 | P00915 | 4/20 | 0.40 |
| ▸ | CA9 | Q16790 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1713038 | 0.98 | CA12 (0.41) | CA12CA1CA9ALDH1A1ALDH2 | |
| Hydrochloric Acid SCHEMBL1535756 | 0.95 | CA12 (0.40) | CA12CA1CA9ALDH1A1ALDH2 | |
| Iodide SCHEMBL7030478 | 0.95 | CA12 (0.40) | CA12CA1CA9ALDH1A1ALDH2 | |
| Fluoride Ion SCHEMBL5446663 | 0.95 | CA12 (0.40) | CA12CA1CA9ALDH1A1ALDH2 | |
| Hydrochloric Acid SCHEMBL6265698 | 0.93 | CA12 (0.39) | CA12CA1CA9ALDH1A1ALDH2 | |
| Hydrochloric Acid SCHEMBL25406366 | 0.91 | CA12 (0.38) | CA12CA1CA9ALDH1A1ALDH2 | |
| SCHEMBL7027230 | 0.90 | CA12 (0.38) | CA12CA1CA9ALDH1A1ALDH2 | |
| Hydrochloric Acid SCHEMBL14862018 | 0.90 | CA12 (0.44) | CA12CA1CA9ALDH1A1ALDH2 | |
| Hydrochloric Acid SCHEMBL25405687 | 0.90 | CA12 (0.42) | CA12CA1CA9ALDH1A1ALDH2 | |
| SCHEMBL7034958 | 0.88 | ALDH1A1 (0.45) | CA12CA1CA9ALDH1A1ALDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115504859-B | Synthesis method of halogenated alkane | 山东同成医药股份有限公司 | 2023-02-28 | — | — | CN | claimed |
| CN-115504859-A | Synthesis method of halogenated alkane | 山东同成医药股份有限公司 | 2022-12-23 | — | — | CN | claimed |
| CN-115417850-B | Application of catalyst containing spiro-cyclic compound in catalyzing reaction of epoxy compound and carbon dioxide | 深圳新宙邦科技股份有限公司 | 2023-04-18 | — | — | CN | disclosed |
| CN-115504859-B | Synthesis method of halogenated alkane | 山东同成医药股份有限公司 | 2023-02-28 | — | — | CN | disclosed |
| CN-115504859-A | Synthesis method of halogenated alkane | 山东同成医药股份有限公司 | 2022-12-23 | — | — | CN | disclosed |
| CN-115417850-A | Application of catalyst containing spiro-cyclic compound in catalyzing reaction of epoxy compound and carbon dioxide | 深圳新宙邦科技股份有限公司 | 2022-12-02 | — | — | CN | disclosed |
| US-9303201-B2 | Method of inhibiting the formation of gas hydrates using amidines and guanidines | ECO INHIBITORS AS (NO) | 2016-04-05 | — | — | US | disclosed |
| US-20140256599-A1 | METHOD OF INHIBITING THE FORMATION OF GAS HYDRATES USING AMIDINES AND GUANIDINES | ECO INHIBITORS AS (NO) | 2014-09-11 | — | — | US | disclosed |
| WO-2013053766-A1 | METHOD OF INHIBITING THE FORMATION OF GAS HYDRATES USING AMIDINES AND GUANIDINES | ECO INHIBITORS AS (NO) | 2013-04-18 | — | — | WO | disclosed |
| EP-0994099-B1 | Process for preparing 4-cyano-3-nitrobenzotrifluoride from 3-bromo-4-cyanobenzotrifluoride in the presence of catalytic cuprous cyanide and a phase transfer catalyst. | BAYER CROPSCIENCE SA (FR) | 2005-02-02 | — | — | EP | disclosed |
| US-6635780-B1 | For preparing intermediates of pesticides (particularly 4-cyano-3-nitrobenzotrifluoride); comprises the reaction of the corresponding ortho-nitrohalobenzene and metal cyanide, in a non aqueous solvent | BAYER CROPSCIENCE S.A. (FR) | 2003-10-21 | — | — | US | disclosed |
| EP-1059291-A2 | Process for preparing bis(ether anhydrides) | GENERAL ELECTRIC COMPANY (US) | 2000-12-13 | — | — | EP | disclosed |
| WO-2000021922-A2 | CHEMICAL PROCESSES | AVENTIS CROPSCIENCE S.A. (FR) | 2000-04-20 | — | — | WO | disclosed |
| EP-0994103-A1 | Processes for preparing pesticidal intermediates | Rhone Poulenc Agro (FR) | 2000-04-19 | — | — | EP | disclosed |
| EP-0994099-A1 | Chemical processes | Rhone Poulenc Agro (FR) | 2000-04-19 | — | — | EP | disclosed |
| US-6008374-A | REACTING N-ALKYL NITROPHTHALIMIDE AND A BISPHENOL ALKALI METAL SALT TO FORM BISIMIDE, EXTRACTING THE FORMED BISIMIDE | GENERAL ELECTRIC COMPANY (US) | 1999-12-28 | — | — | US | disclosed |
| US-5936099-A | N-ALKYL PHTHALAMIDES BY REACTING LIQUID (C3-C6)ALKYLAMINES AND PHTHALIC ANHYDRIDE; NITRATION FOLLOWED BY REACTING WITH A BISPHENOL A; EXCHANGE REACTION TO FORM DIANHYDRIDE; HYDROLYSIS TO PRODUCE TETRACID MONOMER FOR POLYETHERIMIDES | GENERAL ELECTRIC CO. (US) | 1999-08-10 | — | — | US | disclosed |
| US-5719295-A | FROM N-ALKYL NITROPHTHALAMIDE | GENERAL ELECTRIC COMPANY (US) | 1998-02-17 | — | — | US | disclosed |
| US-5536846-A | NITRATION, PURIFICATION, LIQUID EXTRACTION, DRYING AND PURIFICATION THEN REACTION WITH ALKALI METAL BISPHENOL AND TRANSFORMATION | GENERAL ELECTRIC COMPANY (US) | 1996-07-16 | — | — | US | disclosed |
| EP-0684232-A1 | Process for preparing bis(ether anhydrides) | GENERAL ELECTRIC COMPANY (US) | 1995-11-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140256599-A1 | METHOD OF INHIBITING THE FORMATION OF GAS HYDRATES USING AMIDINES AND GUANIDINES | MAGI3, GEMIN5, GCG | CA12 1960/4885CA1 298/4885CA9 193/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.