Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 4/20 | 0.37 |
| ▸ | CA1 | P00915 | 4/20 | 0.37 |
| ▸ | CA9 | Q16790 | 4/20 | 0.37 |
| ▸ | CYP26B1 | Q9NR63 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | EDNRB | P24530 | 1/20 | 0.33 |
| ▸ | EDNRA | P25101 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.32 |
| ▸ | PREP | P48147 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
| ▸ | RHOA | P61586 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6155168 | 1.00 | HSP90AA1 (0.43) | HSP90AA1HSP90AB1CA12CA1CA9 | |
| SCHEMBL6155230 | 0.91 | HSP90AA1 (0.41) | HSP90AA1HSP90AB1CA12CA1CA9 | |
| SCHEMBL6155225 | 0.91 | HSP90AA1 (0.41) | HSP90AA1HSP90AB1CA12CA1CA9 | |
| SCHEMBL6155576 | 0.80 | CA12 (0.42) | HSP90AA1HSP90AB1CA12CA1CA9 | |
| SCHEMBL6155570 | 0.79 | CYP4F2 (0.44) | HSP90AA1HSP90AB1CA12CA1CA9 | |
| SCHEMBL17513851 | 0.78 | HSP90AA1 (0.61) | HSP90AA1HSP90AB1ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL17513850 | 0.78 | HSP90AA1 (0.61) | HSP90AA1HSP90AB1ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL28433092 | 0.76 | HSP90AA1 (0.42) | HSP90AA1HSP90AB1CA12CA1CA9 | |
| SCHEMBL6154937 | 0.74 | KIF11 (0.40) | HSP90AA1CA12CA1CA9CYP26B1 | |
| SCHEMBL6154943 | 0.74 | KIF11 (0.40) | HSP90AA1CA12CA1CA9CYP26B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1124779-B1 | VITAMIN D ANALOGUES | GALDERMA RES & DEV (FR) | 2005-02-02 | — | — | EP | disclosed |
| US-6689922-B1 | BIAROMATIC COMPOUNDS WHICH ARE ANALOGUES OF VITAMIN D HAVE A MARKED ACTIVITY IN THE FIELDS OF CELL DIFFERENTIATION AND PROLIFERATION | GALDERMA RESEARCH & DEVELOPMENT S.N.C. (FR) | 2004-02-10 | — | — | US | disclosed |
| EP-1124779-A1 | VITAMIN D ANALOGUES | Galderma Research & Development, S.N.C. (FR) | 2001-08-22 | — | — | EP | disclosed |
| WO-2000026167-A1 | VITAMIN D ANALOGUES | GALDERMA RESEARCH & DEVELOPMENT, S.N.C. (FR) | 2000-05-11 | — | — | WO | disclosed |