Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 4/20 | 0.66 |
| ▸ | CCND1 | P24385 | 4/20 | 0.66 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.52 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.52 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.51 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6154591 | 1.00 | CDK4 (0.66) | CDK4CCND1HDAC1HDAC6LMNA | |
| SCHEMBL1520321 | 0.88 | LMNA (0.67) | CDK4CCND1HDAC1HDAC6LMNA | |
| SCHEMBL19783673 | 0.84 | CDK4 (0.72) | CDK4CCND1LMNAMAPK1MTNR1A | |
| SCHEMBL30582936 | 0.84 | CDK4 (0.72) | CDK4CCND1LMNAMAPK1MTNR1A | |
| SCHEMBL1269116 | 0.82 | CDK4 (0.71) | CDK4CCND1LMNAMAPK1MTNR1A | |
| SCHEMBL5051883 | 0.81 | LMNA (0.61) | CDK4CCND1LMNAMAPK1MTNR1A | |
| SCHEMBL4327022 | 0.78 | HDAC1 (0.53) | HDAC1HDAC6HDAC3HDAC8HDAC4 | |
| SCHEMBL29560163 | 0.77 | CDK4 (0.68) | CDK4CCND1LMNAMAPK1MTNR1A | |
| SCHEMBL1967792 | 0.77 | CDK4 (0.68) | CDK4CCND1LMNAMAPK1MTNR1A | |
| SCHEMBL24398975 | 0.77 | CDK4 (0.82) | CDK4CCND1LMNAMAPK1MTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358168-B1 | TRICYCLIC LACTAM AND SULTAM DERIVATIVES AND THEIR USE AS HISTONE DEACETYLASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2005-08-10 | — | — | EP | disclosed |