Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.63 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 5/20 | 0.59 |
| ▸ | MEN1 | O00255 | 5/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | CRHBP | P24387 | 2/20 | 0.58 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6811060 | 0.88 | MAPT (0.63) | MAPTTDP1L3MBTL1RAB9ASMN1; SMN2 | |
| SCHEMBL6154649 | 0.77 | MAPT (1.00) | MAPTTDP1L3MBTL1SMN1; SMN2GAA | |
| SCHEMBL6811066 | 0.76 | SETD7 (0.57) | MAPTL3MBTL1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL5457060 | 0.76 | ALDH1A1 (0.68) | MAPTRAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL6815685 | 0.76 | ALDH1A1 (0.65) | MAPTSMN1; SMN2MEN1KMT2ACYP1A2 | |
| SCHEMBL6815664 | 0.75 | MAPT (0.68) | MAPTRAB9ASMN1; SMN2GAAMEN1 | |
| SCHEMBL6154317 | 0.75 | MAPT (0.82) | MAPTTDP1L3MBTL1RAB9AGAA | |
| SCHEMBL6815299 | 0.75 | ALDH1A1 (0.58) | MAPTL3MBTL1RAB9ASMN1; SMN2GAA | |
| SCHEMBL6155197 | 0.74 | GAA (0.74) | MAPTTDP1L3MBTL1RAB9ASMN1; SMN2 | |
| SCHEMBL12305616 | 0.73 | HTT (0.67) | MAPTRAB9ASMN1; SMN2GAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050065118-A1 | Organosulfur inhibitors of tyrosine phosphatases | METABASIS THERAPEUTICS, INC. | 2005-03-24 | — | — | US | disclosed |
| EP-1446110-A2 | ORGANOSULFUR INHIBITORS OF TYROSINE PHOSPHATASES | Structural Bioinformatics Inc. (US) | 2004-08-18 | — | — | EP | disclosed |
| WO-2003032916-A2 | ORGANOSULFUR INHIBITORS OF TYROSINE PHOSPHATASES | STRUCTURAL BIOINFORMATICS INC. (US) | 2003-04-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050065118-A1 | Organosulfur inhibitors of tyrosine phosphatases | PTPRS, PTPRJ, PTPRCAP | MAPT 3318/4885TDP1 219/4885L3MBTL1 279/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.