Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 4/20 | 0.72 |
| ▸ | GAA | P10253 | 6/20 | 0.62 |
| ▸ | MAPT | P10636 | 8/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.61 |
| ▸ | MEN1 | O00255 | 4/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.61 |
| ▸ | PPIA | P62937 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11542953 | 0.84 | ALDH1A1 (0.67) | GAAMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL5988806 | 0.84 | IDO1 (1.00) | IDO1GAAMAPTALDH1A1MEN1 | |
| SCHEMBL14090391 | 0.84 | IDO1 (0.58) | IDO1GAAMAPTALDH1A1KDM4E | |
| SCHEMBL6811589 | 0.83 | ALDH1A1 (0.62) | GAAMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL68180 | 0.82 | MAPT (0.70) | GAAMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL12727642 | 0.81 | MAPT (0.72) | IDO1GAAMAPTALDH1A1MEN1 | |
| SCHEMBL7528507 | 0.79 | SMN1; SMN2 (0.67) | GAAMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL27860200 | 0.79 | KMT2A (0.80) | IDO1GAAMAPTALDH1A1MEN1 | |
| SCHEMBL6814385 | 0.79 | SMN1; SMN2 (0.67) | GAAMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL8419944 | 0.79 | GAA (0.61) | GAAMAPTALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050065118-A1 | Organosulfur inhibitors of tyrosine phosphatases | METABASIS THERAPEUTICS, INC. | 2005-03-24 | — | — | US | disclosed |
| EP-1446110-A2 | ORGANOSULFUR INHIBITORS OF TYROSINE PHOSPHATASES | Structural Bioinformatics Inc. (US) | 2004-08-18 | — | — | EP | disclosed |
| WO-2003032916-A2 | ORGANOSULFUR INHIBITORS OF TYROSINE PHOSPHATASES | STRUCTURAL BIOINFORMATICS INC. (US) | 2003-04-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050065118-A1 | Organosulfur inhibitors of tyrosine phosphatases | PTPRS, PTPRJ, PTPRCAP | IDO1 1533/4885GAA 2365/4885MAPT 3318/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.