SCHEMBL6156380

SCHEMBL6156380

CCC(O)(CC)CCCC(CC)(CC)c1cccc(OCc2ccc(CO)c(CO)c2)c1

nearest known ligand 0.50

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
VDR P11473 3/20 0.50
ALOX5 P09917 7/20 0.43
MAOB P27338 2/20 0.37
BCL2 P10415 1/20 0.36
MRGPRX4 Q96LA9 1/20 0.35
PKM P14618 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4169944 0.89 VDR (0.50) VDRALOX5MAOBBCL2MRGPRX4
SCHEMBL6155102 0.83 VDR (0.41) VDR
SCHEMBL6156388 0.82 ALOX5 (0.39) ALOX5MAOBBCL2
SCHEMBL6158285 0.80 VDR (0.49) VDRMAOBPKM
SCHEMBL2785501 0.80 VDR (0.49) VDRALOX5
SCHEMBL6155129 0.79 VDR (0.48) VDRALOX5BCL2
SCHEMBL6155122 0.79 VDR (0.48) VDR
SCHEMBL6155609 0.78 VDR (0.48) VDRALOX5
SCHEMBL6156099 0.78 VDR (0.48) VDR
SCHEMBL6156102 0.78 VDR (0.48) VDRALOX5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1124779-B1 VITAMIN D ANALOGUES GALDERMA RES & DEV (FR) 2005-02-02 EP claimed
US-6689922-B1 BIAROMATIC COMPOUNDS WHICH ARE ANALOGUES OF VITAMIN D HAVE A MARKED ACTIVITY IN THE FIELDS OF CELL DIFFERENTIATION AND PROLIFERATION GALDERMA RESEARCH & DEVELOPMENT S.N.C. (FR) 2004-02-10 US claimed
EP-1124779-A1 VITAMIN D ANALOGUES Galderma Research & Development, S.N.C. (FR) 2001-08-22 EP claimed
WO-2000026167-A1 VITAMIN D ANALOGUES GALDERMA RESEARCH & DEVELOPMENT, S.N.C. (FR) 2000-05-11 WO claimed
EP-1124779-B1 VITAMIN D ANALOGUES GALDERMA RES & DEV (FR) 2005-02-02 EP disclosed
US-6689922-B1 BIAROMATIC COMPOUNDS WHICH ARE ANALOGUES OF VITAMIN D HAVE A MARKED ACTIVITY IN THE FIELDS OF CELL DIFFERENTIATION AND PROLIFERATION GALDERMA RESEARCH & DEVELOPMENT S.N.C. (FR) 2004-02-10 US disclosed
EP-1124779-A1 VITAMIN D ANALOGUES Galderma Research & Development, S.N.C. (FR) 2001-08-22 EP disclosed
WO-2000026167-A1 VITAMIN D ANALOGUES GALDERMA RESEARCH & DEVELOPMENT, S.N.C. (FR) 2000-05-11 WO disclosed