Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CMA1 | P23946 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 6/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | GSK3A | P49840 | 1/20 | 0.50 |
| ▸ | GSK3B | P49841 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.43 |
| ▸ | DAO | P14920 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12143941 | 0.84 | MAPT (0.56) | CMA1MAPTTP53LMNAGSK3A | |
| SCHEMBL7759057 | 0.81 | MAPT (0.57) | CMA1MAPTTP53LMNAGSK3A | |
| SCHEMBL10621217 | 0.81 | DBH (0.66) | ALDH1A1 | |
| SCHEMBL7325261 | 0.80 | PDE4B (0.57) | MAPTALDH1A1KMT2AGAAPDE4B | |
| SCHEMBL2414081 | 0.79 | MAPK10 (0.50) | LMNAALDH1A1MEN1KMT2AGAA | |
| SCHEMBL7690163 | 0.78 | DBH (0.45) | MAPTTP53ALDH1A1KMT2A | |
| SCHEMBL8583692 | 0.78 | DBH (0.45) | MAPTTP53ALDH1A1 | |
| SCHEMBL6159277 | 0.78 | APLNR (0.49) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL4101771 | 0.78 | DBH (0.62) | CMA1TP53GSK3AGSK3BALDH1A1 | |
| SCHEMBL7759066 | 0.77 | CMA1 (0.57) | CMA1MAPTGSK3AGSK3BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832071-B1 | 1,3-DIHYDRO-2H-IMIDAZOL-2-ONE DERIVATIVES HAVING PDE IV AND CYTOKININ INHIBITING ACTIVITY | JANSSEN PHARMACEUTICA NV (BE) | 2005-09-28 | — | — | EP | disclosed |
| US-5869515-A | TREATING ASTHMATIC OR ATOPIC DISEASES | JANSSEN PHARMACEUTICA N.V. (BE) | 1999-02-09 | — | — | US | disclosed |
| EP-0832071-A1 | 1,3-DIHYDRO-2H-IMIDAZOL-2-ONE DERIVATIVES HAVING PDE IV AND CYTOKININ INHIBITING ACTIVITY | JANSSEN PHARMACEUTICA N.V. (BE) | 1998-04-01 | — | — | EP | disclosed |
| WO-1996031487-A1 | 1,3-DIHYDRO-2H-IMIDAZOL-2-ONE DERIVATIVES HAVING PDE IV AND CYTOKININ INHIBITING ACTIVITY | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-10-10 | — | — | WO | disclosed |