Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | GSK3B | P49841 | 3/20 | 0.46 |
| ▸ | CDK4 | P11802 | 2/20 | 0.46 |
| ▸ | CCND1 | P24385 | 2/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | USP8 | P40818 | 1/20 | 0.43 |
| ▸ | USP7 | Q93009 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11428923 | 0.80 | GSK3B (0.45) | RAB9AALDH1A1POLBGSK3BCDK4 | |
| SCHEMBL7964993 | 0.78 | CA1 (0.56) | RAB9ASMN1; SMN2ALDH1A1POLBGSK3B | |
| SCHEMBL12253692 | 0.76 | RAB9A (0.76) | RAB9ANPC1SMN1; SMN2ALDH1A1POLB | |
| SCHEMBL29378366 | 0.76 | TOP1 (0.55) | ALDH1A1GSK3BCDK4CCND1CCNA2 | |
| SCHEMBL384815 | 0.76 | TOP1 (0.55) | ALDH1A1GSK3BCDK4CCND1CCNA2 | |
| SCHEMBL30615182 | 0.73 | L3MBTL1 (0.55) | RAB9ANPC1SMN1; SMN2ALDH1A1POLB | |
| SCHEMBL28149043 | 0.73 | L3MBTL1 (0.55) | RAB9ANPC1SMN1; SMN2ALDH1A1POLB | |
| SCHEMBL2305964 | 0.73 | RAB9A (0.47) | RAB9ANPC1SMN1; SMN2ALDH1A1POLB | |
| SCHEMBL1097120 | 0.73 | L3MBTL1 (0.55) | RAB9ANPC1SMN1; SMN2ALDH1A1POLB | |
| SCHEMBL18170553 | 0.72 | RAB9A (0.47) | RAB9ANPC1SMN1; SMN2ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0856513-B1 | Thalidomide analogues from the piperidine-2,6-dione class | GRUENENTHAL GMBH (DE) | 2005-11-30 | — | — | EP | claimed |
| EP-1575911-A2 | BIAROMATIC COMPOUNDS WHICH ACTIVATE PPAR-GAMMA TYPE RECEPTORS, AND USE THEREOF IN COSMETIC OR PHARMACEUTICAL COMPOSITIONS | Galderma Research & Development, S.N.C. (FR) | 2005-09-21 | — | — | EP | claimed |
| WO-2004046091-A2 | BIAROMATIC COMPOUNDS WHICH ACTIVATE PPAR-GAMA TYPE RECEPTORS, AND USE THEREOF IN COSMETIC OR PHARMACEUTICAL COMPOSITIONS | GALDERMA RESEARCH & DEVELOPMENT, S.N.C. (FR) | 2004-06-03 | — | — | WO | claimed |
| US-6110941-A | AN IMMUNOMODULATOR MODULATING THE IMMUNE RESPONSE OF A MAMMAL, INHIBITING ANTIGEN-INDUCED SYNTHESIS OF INTERLEUKIN-2 | GRUENENTHAL GMBH (DE) | 2000-08-29 | — | — | US | claimed |
| CN-1190096-A | Compounds analogous to thalidomide from class comprising piperidine-2,6-diones | GRUENENTHAL GMBH (DE) | 1998-08-12 | — | — | CN | claimed |
| EP-0856513-A2 | Thalidomide analogues from the piperidine-2,6-dione class | Grünenthal GmbH (DE) | 1998-08-05 | — | — | EP | claimed |
| US-20240246913-A1 | 2-CARBOXYL-INDOLE INHIBITORS OF METALLO-BETA-LACTAMASES | OXFORD UNIVERSITY INNOVATION LIMITED (GB) | 2024-07-25 | — | — | US | disclosed |
| EP-4347563-A1 | 2-CARBOXYL-INDOLE INHIBITORS OF METALLO-BETA-LACTAMASES | Oxford University Innovation Limited (GB) | 2024-04-10 | — | — | EP | disclosed |
| CN-117677606-A | 2-carboxy-indole inhibitors of metallo-beta-lactamase | 牛津大学创新有限公司 | 2024-03-08 | — | — | CN | disclosed |
| WO-2022248887-A1 | 2-CARBOXYL-INDOLE INHIBITORS OF METALLO-BETA-LACTAMASES | OXFORD UNIVERSITY INNOVATION LIMITED (GB) | 2022-12-01 | — | — | WO | disclosed |
| EP-0856513-B1 | Thalidomide analogues from the piperidine-2,6-dione class | GRUENENTHAL GMBH (DE) | 2005-11-30 | — | — | EP | disclosed |
| EP-1575911-A2 | BIAROMATIC COMPOUNDS WHICH ACTIVATE PPAR-GAMMA TYPE RECEPTORS, AND USE THEREOF IN COSMETIC OR PHARMACEUTICAL COMPOSITIONS | Galderma Research & Development, S.N.C. (FR) | 2005-09-21 | — | — | EP | disclosed |
| WO-2004046091-A2 | BIAROMATIC COMPOUNDS WHICH ACTIVATE PPAR-GAMA TYPE RECEPTORS, AND USE THEREOF IN COSMETIC OR PHARMACEUTICAL COMPOSITIONS | GALDERMA RESEARCH & DEVELOPMENT, S.N.C. (FR) | 2004-06-03 | — | — | WO | disclosed |
| US-6110941-A | AN IMMUNOMODULATOR MODULATING THE IMMUNE RESPONSE OF A MAMMAL, INHIBITING ANTIGEN-INDUCED SYNTHESIS OF INTERLEUKIN-2 | GRUENENTHAL GMBH (DE) | 2000-08-29 | — | — | US | disclosed |
| EP-0856513-A2 | Thalidomide analogues from the piperidine-2,6-dione class | Grünenthal GmbH (DE) | 1998-08-05 | — | — | EP | disclosed |
| EP-0412763-B1 | Cephalosporins, processes for their preparation, pharmaceutical compositions containing them and intermediates therefor | ZENECA LTD (GB) | 1996-07-10 | — | — | EP | disclosed |
| US-5219848-A | Bactericides | ICI PHARMA (FR) | 1993-06-15 | — | — | US | disclosed |
| EP-0412763-A2 | Cephalosporins, processes for their preparation, pharmaceutical compositions containing them and intermediates therefor | ZENECA LIMITED (GB) | 1991-02-13 | — | — | EP | disclosed |
| US-4144072-A | CONTAINING A PHTHALAZINONE AND A PHTHALIMIDE | FUJI PHOTO FILM CO., LTD. (JP) | 1979-03-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240246913-A1 | 2-CARBOXYL-INDOLE INHIBITORS OF METALLO-BETA-LACTAMASES | IDO2, IDO1, COMT | RAB9A 2679/4885NPC1 3704/4885SMN1; SMN2 4150/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.