SCHEMBL6157740

SCHEMBL6157740

NCC(CCCc1cccnc1)c1ccccc1

nearest known ligand 0.57

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 1/20 0.57
HRH1 P35367 2/20 0.54
CHRNA7 P36544 2/20 0.51
TDP1 Q9NUW8 1/20 0.47
L3MBTL1 Q9Y468 1/20 0.47
TBXAS1 P24557 7/20 0.47
HRH4 Q9H3N8 1/20 0.42
HRH3 Q9Y5N1 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6159315 0.96 HRH1 (0.56) CYP2A6HRH1CHRNA7TDP1L3MBTL1
SCHEMBL6160319 0.90 CYP2A6 (0.64) CYP2A6HRH1CHRNA7TDP1L3MBTL1
SCHEMBL6158950 0.90 CYP2A6 (0.59) CYP2A6HRH1CHRNA7TDP1L3MBTL1
SCHEMBL6161202 0.86 HRH1 (0.59) CYP2A6HRH1CHRNA7TDP1L3MBTL1
SCHEMBL6159264 0.86 HRH1 (0.63) CYP2A6HRH1CHRNA7TDP1L3MBTL1
SCHEMBL8091508 0.85 CYP2A6 (0.49) CYP2A6HRH1CHRNA7TDP1L3MBTL1
SCHEMBL8095259 0.80 CYP2A6 (0.43) CYP2A6HRH1TDP1L3MBTL1TBXAS1
SCHEMBL28012512 0.79 L3MBTL1 (0.54) CYP2A6HRH1CHRNA7TDP1L3MBTL1
SCHEMBL14244978 0.78 HTR2A (0.53)
SCHEMBL6159713 0.77 CFTR (0.45) CYP2A6TDP1L3MBTL1TBXAS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1129070-A4 NEUROTROPHIC DIAMIDE AND CARBAMATE AGENTS BRISTOL MYERS SQUIBB CO (US) 2005-03-02 EP disclosed
EP-1129070-A1 NEUROTROPHIC DIAMIDE AND CARBAMATE AGENTS BRISTOL-MYERS SQUIBB COMPANY (US) 2001-09-05 EP disclosed
US-6228872-B1 PEPTIDE-PROLYL ISOMERASE AND ROTAMASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY 2001-05-08 US disclosed
WO-2000027811-A1 NEUROTROPHIC DIAMIDE AND CARBAMATE AGENTS BRISTOL-MYERS SQUIBB COMPANY (US) 2000-05-18 WO disclosed