SCHEMBL6159264

SCHEMBL6159264

NCCCC(CCCCc1cccnc1)c1ccccc1

nearest known ligand 0.63

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
HRH1 P35367 3/20 0.63
CYP2A6 P11509 1/20 0.62
CHRNA7 P36544 1/20 0.53
TDP1 Q9NUW8 1/20 0.49
L3MBTL1 Q9Y468 1/20 0.49
TBXAS1 P24557 7/20 0.48
MAOA P21397 1/20 0.45
HTR2A P28223 1/20 0.44
PTAFR P25105 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6160319 0.96 CYP2A6 (0.64) HRH1CYP2A6CHRNA7TDP1L3MBTL1
SCHEMBL6161202 0.94 HRH1 (0.59) HRH1CYP2A6CHRNA7TDP1L3MBTL1
SCHEMBL6158950 0.90 CYP2A6 (0.59) HRH1CYP2A6CHRNA7TDP1L3MBTL1
SCHEMBL6159315 0.90 HRH1 (0.56) HRH1CYP2A6CHRNA7TDP1L3MBTL1
SCHEMBL6157740 0.86 CYP2A6 (0.57) HRH1CYP2A6CHRNA7TDP1L3MBTL1
SCHEMBL11187960 0.80 MAOA (0.59) HRH1CYP2A6MAOAHTR2A
SCHEMBL8091508 0.80 CYP2A6 (0.49) HRH1CYP2A6CHRNA7TDP1L3MBTL1
SCHEMBL2673539 0.80 HRH1 (0.96) HRH1CYP2A6CHRNA7TDP1L3MBTL1
SCHEMBL4962152 0.78 HRH1 (1.00) HRH1CYP2A6CHRNA7TDP1L3MBTL1
SCHEMBL11214933 0.78 HRH1 (1.00) HRH1CYP2A6CHRNA7TDP1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1129070-A4 NEUROTROPHIC DIAMIDE AND CARBAMATE AGENTS BRISTOL MYERS SQUIBB CO (US) 2005-03-02 EP disclosed
EP-1129070-A1 NEUROTROPHIC DIAMIDE AND CARBAMATE AGENTS BRISTOL-MYERS SQUIBB COMPANY (US) 2001-09-05 EP disclosed
US-6228872-B1 PEPTIDE-PROLYL ISOMERASE AND ROTAMASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY 2001-05-08 US disclosed
WO-2000027811-A1 NEUROTROPHIC DIAMIDE AND CARBAMATE AGENTS BRISTOL-MYERS SQUIBB COMPANY (US) 2000-05-18 WO disclosed