Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 5/20 | 0.47 |
| ▸ | ECE1 | P42892 | 6/20 | 0.36 |
| ▸ | MMP2 | P08253 | 3/20 | 0.32 |
| ▸ | MMP8 | P22894 | 2/20 | 0.32 |
| ▸ | MMP1 | P03956 | 2/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.31 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6158476 | 0.90 | CASP1 (0.59) | CASP1ECE1MMP2MMP8MMP1 | |
| SCHEMBL6158315 | 0.83 | CASP1 (0.62) | CASP1ECE1 | |
| SCHEMBL6158353 | 0.81 | CASP1 (0.53) | CASP1MMP2MMP8MMP1MMP9 | |
| SCHEMBL6159070 | 0.81 | CASP1 (0.56) | CASP1MMP2MMP8MMP1MMP9 | |
| SCHEMBL6160008 | 0.77 | CASP1 (0.72) | CASP1MMP2MMP8MMP1MMP9 | |
| SCHEMBL6160628 | 0.76 | CASP1 (0.61) | CASP1MMP2MMP1 | |
| SCHEMBL6158329 | 0.75 | CASP1 (0.58) | CASP1 | |
| SCHEMBL6158472 | 0.73 | CASP1 (0.77) | CASP1ECE1MMP2MMP8MMP1 | |
| SCHEMBL6159523 | 0.72 | CASP1 (0.57) | CASP1MMP2MMP8MMP1MMP9 | |
| SCHEMBL6160003 | 0.71 | CASP1 (0.60) | CASP1MMP2MMP8MMP1MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1082127-B1 | SUCCINAMIDE INHIBITORS OF INTERLEUKIN-1BETA CONVERTING ENZYME | WARNER LAMBERT CO (US) | 2005-06-22 | — | — | EP | claimed |
| EP-1082127-B1 | SUCCINAMIDE INHIBITORS OF INTERLEUKIN-1BETA CONVERTING ENZYME | WARNER LAMBERT CO (US) | 2005-06-22 | — | — | EP | disclosed |
| EP-1082127-A4 | SUCCINAMIDE INHIBITORS OF INTERLEUKIN-1$g(b) CONVERTING ENZYME | WARNER LAMBERT CO (US) | 2002-10-09 | — | — | EP | disclosed |
| EP-1082127-A1 | SUCCINAMIDE INHIBITORS OF INTERLEUKIN-1$g(b) CONVERTING ENZYME | WARNER-LAMBERT COMPANY (US) | 2001-03-14 | — | — | EP | disclosed |
| WO-1999056765-A1 | SUCCINAMIDE INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME | WARNER-LAMBERT COMPANY (US) | 1999-11-11 | — | — | WO | disclosed |