Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 13/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 2/20 | 0.35 |
| ▸ | CASP6 | P55212 | 2/20 | 0.35 |
| ▸ | CASP8 | Q14790 | 2/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6160628 | 0.95 | CASP1 (0.61) | CASP1CASP3CASP6CASP8 | |
| SCHEMBL6158679 | 0.89 | CASP1 (0.74) | CASP1KMT2AALDH1A1CYP2C19 | |
| SCHEMBL6158315 | 0.85 | CASP1 (0.62) | CASP1KMT2AALDH1A1CYP2D6CYP2C9 | |
| SCHEMBL6160169 | 0.84 | CASP1 (0.78) | CASP1KMT2AALDH1A1CYP2C19 | |
| SCHEMBL6157518 | 0.83 | CASP1 (0.69) | CASP1KMT2AALDH1A1CYP2C19 | |
| SCHEMBL6159134 | 0.83 | CASP1 (0.68) | CASP1KMT2AALDH1A1CYP2C19 | |
| SCHEMBL6157780 | 0.82 | CASP1 (0.69) | CASP1KMT2AALDH1A1CYP2C19 | |
| SCHEMBL6159401 | 0.82 | CASP1 (0.67) | CASP1KMT2AALDH1A1CYP2C19 | |
| SCHEMBL6158325 | 0.81 | CASP1 (0.50) | CASP1KMT2AALDH1A1HPGDCASP3 | |
| SCHEMBL6159750 | 0.80 | CASP1 (0.75) | CASP1KMT2ACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1082127-B1 | SUCCINAMIDE INHIBITORS OF INTERLEUKIN-1BETA CONVERTING ENZYME | WARNER LAMBERT CO (US) | 2005-06-22 | — | — | EP | claimed |
| EP-1082127-B1 | SUCCINAMIDE INHIBITORS OF INTERLEUKIN-1BETA CONVERTING ENZYME | WARNER LAMBERT CO (US) | 2005-06-22 | — | — | EP | disclosed |