Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 9/20 | 0.46 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.38 |
| ▸ | REN | P00797 | 2/20 | 0.35 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | MMP8 | P22894 | 1/20 | 0.31 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.31 |
| ▸ | PSMD11 | O00231 | 1/20 | 0.31 |
| ▸ | PSMD12 | O00232 | 1/20 | 0.31 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.31 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.31 |
| ▸ | PSMD3 | O43242 | 1/20 | 0.31 |
| ▸ | PSMC3 | P17980 | 1/20 | 0.31 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6158140 | 0.93 | CASP1 (0.51) | CASP1ALDH1A1MMP1MMP2MMP9 | |
| SCHEMBL6159126 | 0.92 | CASP1 (0.47) | CASP1KCNA5CPB2 | |
| SCHEMBL6157498 | 0.89 | CASP1 (0.47) | CASP1MMP1MMP2PSMB11PSMD11 | |
| SCHEMBL6158942 | 0.89 | CASP1 (0.54) | CASP1MMP1MMP2 | |
| SCHEMBL6159512 | 0.88 | CASP1 (0.49) | CASP1KCNA5CPB2MMP2MMP9 | |
| SCHEMBL6157776 | 0.88 | CASP1 (0.48) | CASP1 | |
| SCHEMBL6158146 | 0.86 | CASP1 (0.47) | CASP1 | |
| SCHEMBL6158910 | 0.85 | CASP1 (0.52) | CASP1 | |
| SCHEMBL6159714 | 0.84 | CASP1 (0.51) | CASP1MMP2MMP9MMP8 | |
| SCHEMBL6157768 | 0.84 | CASP1 (0.41) | CASP1MMP1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1082127-B1 | SUCCINAMIDE INHIBITORS OF INTERLEUKIN-1BETA CONVERTING ENZYME | WARNER LAMBERT CO (US) | 2005-06-22 | — | — | EP | claimed |
| EP-1082127-B1 | SUCCINAMIDE INHIBITORS OF INTERLEUKIN-1BETA CONVERTING ENZYME | WARNER LAMBERT CO (US) | 2005-06-22 | — | — | EP | disclosed |