Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 13/20 | 0.49 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 2/20 | 0.32 |
| ▸ | CASP6 | P55212 | 2/20 | 0.32 |
| ▸ | CASP8 | Q14790 | 2/20 | 0.32 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | CA5A | P35218 | 2/20 | 0.32 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | MMP8 | P22894 | 1/20 | 0.31 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6159126 | 0.96 | CASP1 (0.47) | CASP1CPB2KCNA5 | |
| SCHEMBL6158942 | 0.94 | CASP1 (0.54) | CASP1CASP3CASP6CASP8MMP2 | |
| SCHEMBL6158140 | 0.90 | CASP1 (0.51) | CASP1CASP3CASP6CASP8MMP2 | |
| SCHEMBL6159714 | 0.89 | CASP1 (0.51) | CASP1CASP3CASP6CASP8MMP2 | |
| SCHEMBL6157498 | 0.89 | CASP1 (0.47) | CASP1CA1CA2CA5ACA5B | |
| SCHEMBL6158658 | 0.88 | CASP1 (0.46) | CASP1CPB2MMP2MMP9MMP8 | |
| SCHEMBL6159642 | 0.85 | CASP1 (0.49) | CASP1CASP3CASP6CASP8 | |
| SCHEMBL6157776 | 0.85 | CASP1 (0.48) | CASP1CASP3CASP6 | |
| SCHEMBL6159608 | 0.85 | CASP1 (0.43) | CASP1 | |
| SCHEMBL6159199 | 0.84 | CASP1 (0.54) | CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1082127-B1 | SUCCINAMIDE INHIBITORS OF INTERLEUKIN-1BETA CONVERTING ENZYME | WARNER LAMBERT CO (US) | 2005-06-22 | — | — | EP | claimed |
| EP-1082127-B1 | SUCCINAMIDE INHIBITORS OF INTERLEUKIN-1BETA CONVERTING ENZYME | WARNER LAMBERT CO (US) | 2005-06-22 | — | — | EP | disclosed |