Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2013019 | 0.69 | TSHR (0.33) | TSHR | |
| SCHEMBL2012033 | 0.62 | MAPT (0.36) | TSHR | |
| SCHEMBL2011424 | 0.62 | TSHR (0.35) | TSHR | |
| SCHEMBL2014151 | 0.61 | HTT (0.41) | — | |
| SCHEMBL2012353 | 0.58 | TSHR (0.37) | TSHR | |
| SCHEMBL12155298 | 0.56 | CACNA1I (0.48) | — | |
| SCHEMBL473047 | 0.56 | GLS (0.47) | TSHR | |
| SCHEMBL1005092 | 0.56 | GLS (0.47) | TSHR | |
| SCHEMBL13965733 | 0.55 | OPRD1 (0.50) | — | |
| SCHEMBL13965722 | 0.55 | OPRD1 (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6852875-B2 | Synthesis of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester using oxazolidinone derivatives | THE NUTRASWEET CO. (US) | 2005-02-08 | — | — | US | disclosed |
| EP-1284991-B1 | SYNTHESIS OF N-[N-(3,3-DIMETHYLBUTYL)-L-ALPHA-ASPARTYL]-L-PHENYLALANINE 1-METHYL ESTER USING OXAZOLIDINONE DERIVATIVES | NUTRASWEET CO (US) | 2005-02-02 | — | — | EP | disclosed |
| US-20050014967-A1 | Synthesis of N-[N-(3,3-dimethylbutyl)-L-alpha-aspartyl]-L-phenylalanine 1-methyl ester using oxazolidinone derivatives | THE NUTRASWEET COMPANY (US) | 2005-01-20 | — | — | US | disclosed |
| EP-1284991-A2 | SYNTHESIS OF N-[N-(3,3-DIMETHYLBUTYL)-L-ALPHA-ASPARTYL]-L-PHENYLALANINE 1-METHYL ESTER USING OXAZOLIDINONE DERIVATIVES | The NutraSweet Company (US) | 2003-02-26 | — | — | EP | disclosed |
| US-20020013490-A1 | Synthesis of N- [N-(3,3-dimethylbutyl)-L-alpha-aspartyl] -L-phenylalantine 1-methyl ester using oxazolidinone derivatives | THE NUTRASWEET COMPANY | 2002-01-31 | — | — | US | disclosed |
| WO-2001090138-A2 | SYNTHESIS OF N-[N-(3,3-DIMETHYLBUTYL)-L-α-ASPARTYL]-L-PHENYLALANINE 1-METHYL ESTER USING OXAZOLIDINONE DERIVATIVES | THE NUTRASWEET COMPANY (US) | 2001-11-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020013490-A1 | Synthesis of N- [N-(3,3-dimethylbutyl)-L-alpha-aspartyl] -L-phenylalantine 1-methyl ester using oxazolidinone derivatives | DNPEP, PEPD, ANPEP | TSHR 4659/4885 |
| US-20050014967-A1 | Synthesis of N-[N-(3,3-dimethylbutyl)-L-alpha-aspartyl]-L-phenylalanine 1-methyl ester using oxazolidinone derivatives | DNPEP, PEPD, NAALAD2 | TSHR 4738/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.