Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR88 | Q9GZN0 | 4/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.37 |
| ▸ | TACR1 | P25103 | 1/20 | 0.36 |
| ▸ | TACR3 | P29371 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | NPY1R | P25929 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6158915 | 0.94 | GPR88 (0.35) | GPR88F10PRSS1TACR1TACR3 | |
| SCHEMBL6158939 | 0.90 | F10 (0.38) | GPR88F10PRSS1TACR1TACR3 | |
| SCHEMBL1362522 | 0.77 | TACR1 (0.55) | GPR88F10PRSS1TACR1TACR3 | |
| SCHEMBL1362496 | 0.76 | GAA (0.39) | GPR88TACR1TACR3TP53 | |
| SCHEMBL1362244 | 0.75 | CYP3A4 (0.47) | F10PRSS1TACR1TACR3CNR1 | |
| SCHEMBL1361676 | 0.74 | SMN1; SMN2 (0.51) | ALDH1A1 | |
| SCHEMBL1362526 | 0.74 | CTSS (0.41) | F10PRSS1NPSR1 | |
| SCHEMBL6617399 | 0.74 | ACE (0.46) | CNR1CNR2 | |
| SCHEMBL1363693 | 0.72 | PARP10 (0.52) | GPR88ALDH1A1NPSR1 | |
| SCHEMBL2945634 | 0.71 | MME (0.48) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501813-B1 | Benzothiadiazepine derivatives, processes for their preparation and pharmaceutical compositions containing them | ALBIREO AB (SE) | 2013-08-14 | — | — | EP | disclosed |
| EP-1597245-A1 | BENZOTHIAZEPINE AND BENZOTHIEPINE DERIVATIVES | AstraZeneca AB (SE) | 2005-11-23 | — | — | EP | disclosed |
| EP-1501813-A2 | BENZOTHIADIAZEPINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Astrazeneca AB (SE) | 2005-02-02 | — | — | EP | disclosed |
| WO-2004076430-A1 | BENZOTHIAZEPINE AND BENZOTHIEPINE DERIVATIVES | ASTRAZENECA AB (SE) | 2004-09-10 | — | — | WO | disclosed |
| WO-2003091232-A2 | BENZOTHIADIAZEPINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ASTRAZENECA AB (SE) | 2003-11-06 | — | — | WO | disclosed |