Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 1/20 | 0.60 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | MMP8 | P22894 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | EDNRA | P25101 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | EDNRB | P24530 | 1/20 | 0.30 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6157940 | 0.92 | CASP1 (0.72) | CASP1MMP9MMP8MEN1KMT2A | |
| SCHEMBL6157768 | 0.85 | CASP1 (0.41) | CASP1 | |
| SCHEMBL6159173 | 0.83 | CASP1 (0.84) | CASP1MMP9MMP8MEN1KMT2A | |
| SCHEMBL6159573 | 0.82 | CASP1 (0.58) | CASP1MEN1KMT2AEDNRAKDM4E | |
| SCHEMBL6158942 | 0.79 | CASP1 (0.54) | CASP1 | |
| SCHEMBL6159199 | 0.79 | CASP1 (0.54) | CASP1MEN1KMT2AKDM4EHSD17B10 | |
| SCHEMBL6158910 | 0.77 | CASP1 (0.52) | CASP1 | |
| SCHEMBL6158140 | 0.76 | CASP1 (0.51) | CASP1MMP9MMP8KMT2AHPGD | |
| SCHEMBL6159714 | 0.76 | CASP1 (0.51) | CASP1MMP9MMP8 | |
| SCHEMBL6160002 | 0.75 | CASP1 (1.00) | CASP1MMP9MMP8MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1082127-B1 | SUCCINAMIDE INHIBITORS OF INTERLEUKIN-1BETA CONVERTING ENZYME | WARNER LAMBERT CO (US) | 2005-06-22 | — | — | EP | claimed |
| EP-1082127-B1 | SUCCINAMIDE INHIBITORS OF INTERLEUKIN-1BETA CONVERTING ENZYME | WARNER LAMBERT CO (US) | 2005-06-22 | — | — | EP | disclosed |