Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 12/20 | 0.65 |
| ▸ | TPSAB1 | Q15661 | 3/20 | 0.65 |
| ▸ | F2 | P00734 | 3/20 | 0.65 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.65 |
| ▸ | PLG | P00747 | 1/20 | 0.65 |
| ▸ | PLAU | P00749 | 1/20 | 0.65 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.65 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.65 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.64 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.64 |
| ▸ | F7 | P08709 | 2/20 | 0.62 |
| ▸ | KLK1 | P06870 | 1/20 | 0.47 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30697529 | 0.91 | F10 (0.80) | F10TPSAB1F2PRSS1PLG | |
| SCHEMBL65730 | 0.88 | F10 (0.77) | F10TPSAB1F2PRSS1PLG | |
| SCHEMBL4322200 | 0.87 | TPSAB1 (0.78) | F10TPSAB1F2PRSS1PLG | |
| SCHEMBL6163820 | 0.84 | F10 (0.85) | F10TPSAB1F2PRSS1PLG | |
| SCHEMBL7403124 | 0.84 | F10 (0.67) | F10TPSAB1F2PRSS1PLG | |
| SCHEMBL7406863 | 0.83 | F10 (0.76) | F10TPSAB1F2PRSS1PLG | |
| Hydrochloric Acid SCHEMBL28579078 | 0.83 | F10 (0.82) | F10TPSAB1F2PRSS1PLG | |
| Hydrochloric Acid SCHEMBL30386514 | 0.83 | F10 (0.82) | F10TPSAB1F2PRSS1PLG | |
| SCHEMBL7405535 | 0.82 | F10 (0.65) | F10TPSAB1F2PRSS1PLG | |
| SCHEMBL7406681 | 0.82 | F10 (0.68) | F10TPSAB1F2PRSS1PLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0943008-B1 | METAL MEDIATED SERINE PROTEASE INHIBITORS | AXYS PHARM INC (US) | 2005-11-09 | — | — | EP | disclosed |
| US-6355460-B1 | DETECTING ENZYME INHIBITORS; INCUBATE ENZYME WITH MODULATOR, MONITOR SAMPLE FOR REDUCTION IN ENZYME ACTIVITY, REDUCTION IN ENZYME ACTIVITY INDICATES MODULATOR | AXYS PHARMACEUTICALS, INC. | 2002-03-12 | — | — | US | disclosed |
| US-6255091-B1 | ASSAYING FOR ENHANCED INHIBITION OF SERINE PROTEASE IN A MEDIUM THAT IS DEVOID OF DISSACIATED DIVALENT METAL CATIONS | AXYS PHARMACEUTICALS, INC. | 2001-07-03 | — | — | US | disclosed |
| EP-0943008-A1 | METAL MEDIATED SERINE PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 1999-09-22 | — | — | EP | disclosed |
| WO-1998022619-A1 | METAL MEDIATED SERINE PROTEASE INHIBITORS | ARRIS PHARMACEUTICAL CORPORATION (US) | 1998-05-28 | — | — | WO | disclosed |