Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.60 |
| ▸ | F10 | P00742 | 1/20 | 0.60 |
| ▸ | F7 | P08709 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 4/20 | 0.59 |
| ▸ | RAD52 | P43351 | 1/20 | 0.57 |
| ▸ | UBE2N | P61088 | 1/20 | 0.57 |
| ▸ | PKM | P14618 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.54 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 3/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6159254 | 0.91 | GAA (0.59) | F2F10F7GAAPKM | |
| SCHEMBL7072252 | 0.89 | RAD52 (0.59) | F2F10F7GAARAD52 | |
| SCHEMBL7272943 | 0.86 | GAA (0.75) | GAAPKMMAPTGRIN1GRIN2B | |
| SCHEMBL6159269 | 0.84 | POLB (0.70) | F2F10GAARAD52UBE2N | |
| SCHEMBL7071785 | 0.82 | LMNA (0.66) | F2F10F7GAARAD52 | |
| SCHEMBL9043160 | 0.82 | MAPT (0.49) | F2F10F7GAARAD52 | |
| SCHEMBL230024 | 0.82 | GAA (0.78) | F2F10F7GAAPKM | |
| SCHEMBL7504400 | 0.81 | GRIN1 (0.77) | GAARAD52UBE2NPKMMAPT | |
| SCHEMBL5795499 | 0.79 | GAA (0.64) | GAAPKMMAPTGRIN1GRIN2B | |
| SCHEMBL29450860 | 0.78 | DDAH1 (0.66) | GAAPKMPOLBTSHRNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0943008-B1 | METAL MEDIATED SERINE PROTEASE INHIBITORS | AXYS PHARM INC (US) | 2005-11-09 | — | — | EP | disclosed |
| US-6355460-B1 | DETECTING ENZYME INHIBITORS; INCUBATE ENZYME WITH MODULATOR, MONITOR SAMPLE FOR REDUCTION IN ENZYME ACTIVITY, REDUCTION IN ENZYME ACTIVITY INDICATES MODULATOR | AXYS PHARMACEUTICALS, INC. | 2002-03-12 | — | — | US | disclosed |
| US-6255091-B1 | ASSAYING FOR ENHANCED INHIBITION OF SERINE PROTEASE IN A MEDIUM THAT IS DEVOID OF DISSACIATED DIVALENT METAL CATIONS | AXYS PHARMACEUTICALS, INC. | 2001-07-03 | — | — | US | disclosed |
| EP-0943008-A1 | METAL MEDIATED SERINE PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 1999-09-22 | — | — | EP | disclosed |
| WO-1998022619-A1 | METAL MEDIATED SERINE PROTEASE INHIBITORS | ARRIS PHARMACEUTICAL CORPORATION (US) | 1998-05-28 | — | — | WO | disclosed |