Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 1/20 | 0.49 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | FABP3 | P05413 | 1/20 | 0.42 |
| ▸ | FABP4 | P15090 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10710768 | 0.82 | NCF1 (0.47) | NCF1KEAP1MAPK1GAAFABP3 | |
| Hydrochloric Acid SCHEMBL29156848 | 0.82 | KEAP1 (0.52) | NCF1KEAP1MAPK1GAAFABP3 | |
| Hydrochloric Acid SCHEMBL10712688 | 0.82 | NCF1 (0.47) | NCF1KEAP1MAPK1GAAFABP3 | |
| SCHEMBL8776692 | 0.81 | NCF1 (0.54) | NCF1KEAP1MAPK1GAAFABP3 | |
| SCHEMBL28053480 | 0.79 | NCF1 (0.49) | NCF1KEAP1MAPK1GAAFABP3 | |
| SCHEMBL721985 | 0.79 | NCF1 (0.49) | NCF1KEAP1MAPK1GAAFABP3 | |
| SCHEMBL6514775 | 0.79 | KEAP1 (0.53) | NCF1KEAP1MAPK1GAAFABP3 | |
| SCHEMBL111729 | 0.79 | NCF1 (0.72) | NCF1KEAP1MAPK1GAAFABP3 | |
| Nitrogen SCHEMBL4600854 | 0.78 | NCF1 (0.51) | NCF1KEAP1MAPK1GAAFABP3 | |
| SCHEMBL11305984 | 0.78 | KEAP1 (0.52) | NCF1KEAP1MAPK1GAAFABP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1237877-B1 | CARBOXAMIDE-SUBSTITUTED BENZIMIDAZOL DERIVATIVES, METHODS FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA (DE) | 2005-07-27 | — | — | EP | claimed |
| EP-1237877-A2 | CARBOXAMIDE-SUBSTITUTED BENZIMIDAZOL DERIVATIVES, METHODS FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICAMENTS | BOEHRINGER INGELHEIM KG (DE) | 2002-09-11 | — | — | EP | claimed |
| US-6407130-B1 | ANTIALLERGENS, ANTIINFLAMMATORY AND ANTIARTHRITIC AGENTS; RESPIRATORY SYSTEM, GASTROINTESTINAL DISORDERS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-06-18 | — | — | US | claimed |
| WO-2001034572-A2 | CARBOXAMIDE-SUBSTITUTED BENZIMIDAZOL DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS TRYPTASE INHIBITORS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-05-17 | — | — | WO | claimed |
| EP-1237877-B1 | CARBOXAMIDE-SUBSTITUTED BENZIMIDAZOL DERIVATIVES, METHODS FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA (DE) | 2005-07-27 | — | — | EP | disclosed |
| EP-1237877-A2 | CARBOXAMIDE-SUBSTITUTED BENZIMIDAZOL DERIVATIVES, METHODS FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICAMENTS | BOEHRINGER INGELHEIM KG (DE) | 2002-09-11 | — | — | EP | disclosed |
| US-6407130-B1 | ANTIALLERGENS, ANTIINFLAMMATORY AND ANTIARTHRITIC AGENTS; RESPIRATORY SYSTEM, GASTROINTESTINAL DISORDERS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-06-18 | — | — | US | disclosed |
| WO-2001034572-A2 | CARBOXAMIDE-SUBSTITUTED BENZIMIDAZOL DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS TRYPTASE INHIBITORS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-05-17 | — | — | WO | disclosed |