Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 18/20 | 0.48 |
| ▸ | CDK4 | P11802 | 10/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 9/20 | 0.48 |
| ▸ | PLK1 | P53350 | 1/20 | 0.48 |
| ▸ | CDK9 | P50750 | 14/20 | 0.47 |
| ▸ | CDK1 | P06493 | 10/20 | 0.47 |
| ▸ | CDK7 | P50613 | 10/20 | 0.47 |
| ▸ | AURKA | O14965 | 6/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 8/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 5/20 | 0.46 |
| ▸ | CCNH | P51946 | 5/20 | 0.46 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.46 |
| ▸ | FLT3 | P36888 | 2/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.42 |
| ▸ | WEE1 | P30291 | 2/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6159471 | 0.85 | CDK2 (0.59) | CDK2CDK4PLK1CDK9CDK1 | |
| SCHEMBL6409152 | 0.81 | CDK2 (0.65) | CDK2CDK4CCNA2CDK9CDK1 | |
| SCHEMBL4169064 | 0.78 | CDK2 (0.68) | CDK2CDK4CCNA2PLK1CDK9 | |
| SCHEMBL7465490 | 0.78 | ALDH1A1 (0.47) | CDK2CDK4CDK9CDK1CDK7 | |
| SCHEMBL6158084 | 0.75 | CDK2 (0.78) | CDK2CDK4CCNA2PLK1CDK9 | |
| SCHEMBL5613959 | 0.72 | WEE1 (0.58) | CDK2CDK4CCNA2CDK9CDK1 | |
| SCHEMBL19554159 | 0.72 | KDM4E (0.41) | — | |
| SCHEMBL1888365 | 0.70 | CDK2 (0.55) | CDK2CDK4CCNA2PLK1CDK9 | |
| SCHEMBL29941155 | 0.69 | CDK2 (0.53) | CDK2CDK4CCNA2PLK1CDK9 | |
| SCHEMBL27624138 | 0.69 | CDK2 (0.61) | CDK2CDK4CCNA2PLK1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581231-A1 | ANTI-VIRAL COMPOUNDS | Cyclacel Limited (GB) | 2005-10-05 | — | — | EP | disclosed |
| EP-1430051-A1 | N-(4-(4-METHYLTHIAZOL-5-YL)PYRIMIDIN-2-YL)-N-PHENYLAMINES AS ANTIPROLIFERATIVE COMPOUNDS | Cyclacel Limited (GB) | 2004-06-23 | — | — | EP | disclosed |
| WO-2004043467-A1 | ANTI-VIRAL COMPOUNDS | CYCLACEL LIMITED (GB) | 2004-05-27 | — | — | WO | disclosed |
| WO-2003029248-A1 | N-(4-(4-METHYLTHIAZOL-5-YL) PYRIMIDIN-2-YL) -N-PHENYLAMINES AS ANTIPROLIFERATIVE COMPOUNDS | CYCLACEL LIMITED (GB) | 2003-04-10 | — | — | WO | disclosed |