SCHEMBL6159996

SCHEMBL6159996

CC(=O)N(c1ccccc1)C1CCN(C(=O)C(Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)CC1

nearest known ligand 0.55

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
GHSR Q92847 11/20 0.51
OPRM1 P35372 1/20 0.51
ACE P12821 1/20 0.49
MEN1 O00255 2/20 0.48
KMT2A Q03164 2/20 0.48
PKM P14618 1/20 0.48
CALCRL Q16602 1/20 0.47
FPR2 P25090 1/20 0.47
MMP2 P08253 1/20 0.45
MMP9 P14780 1/20 0.45
MMP8 P22894 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6159993 1.00 GHSR (0.51) GHSROPRM1ACEMEN1KMT2A
SCHEMBL6161878 0.88 MEN1 (0.55) ACEMEN1KMT2APKMFPR2
SCHEMBL6161880 0.88 MEN1 (0.55) ACEMEN1KMT2APKMFPR2
SCHEMBL6160217 0.85 GHSR (0.55) GHSROPRM1ACEMEN1KMT2A
SCHEMBL6160232 0.85 GHSR (0.55) GHSROPRM1ACEMEN1KMT2A
SCHEMBL6171255 0.85 BCHE (0.51) GHSROPRM1ACEMEN1KMT2A
SCHEMBL6171262 0.85 BCHE (0.51) GHSROPRM1ACEMEN1KMT2A
Hydrochloric Acid SCHEMBL6161051 0.84 GHSR (0.54) GHSROPRM1ACEMEN1KMT2A
Hydrochloric Acid SCHEMBL6161057 0.84 GHSR (0.54) GHSROPRM1ACEMEN1KMT2A
SCHEMBL6161841 0.83 GHSR (0.54) GHSROPRM1ACEMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0828754-B1 DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE PFIZER (US) 2005-02-02 EP claimed
EP-0828754-A1 DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE PFIZER INC. (US) 1998-03-18 EP claimed
CN-1143647-A Dipeptides which promote release of growth hormone PFIZER (US) 1997-02-26 CN claimed
WO-1996038471-A1 DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE PFIZER INC. (US) 1996-12-05 WO claimed
WO-1996035713-A1 DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE PFIZER, INC. (US) 1996-11-14 WO claimed
EP-0828754-B1 DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE PFIZER (US) 2005-02-02 EP disclosed
EP-0828754-A1 DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE PFIZER INC. (US) 1998-03-18 EP disclosed
CN-1143647-A Dipeptides which promote release of growth hormone PFIZER (US) 1997-02-26 CN disclosed
WO-1996038471-A1 DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE PFIZER INC. (US) 1996-12-05 WO disclosed
WO-1996035713-A1 DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE PFIZER, INC. (US) 1996-11-14 WO disclosed