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SCHEMBL6161878

SCHEMBL6161878

CC(=O)N(c1ccccc1)C1CCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)NC(=O)OC(C)(C)C)CC1

nearest known ligand 0.63

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 1/20 0.55
▸ KMT2A Q03164 1/20 0.55
▸ CTSL P07711 2/20 0.47
▸ CTSS P25774 1/20 0.47
▸ CTSK P43235 1/20 0.47
▸ PKM P14618 1/20 0.46
▸ FPR2 P25090 1/20 0.45
▸ CCKAR P32238 1/20 0.45
▸ ACE P12821 2/20 0.45
▸ TACR1 P25103 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6161880 1.00 MEN1 (0.55) MEN1KMT2ACTSLCTSSCTSK
SCHEMBL6159993 0.88 GHSR (0.51) MEN1KMT2APKMFPR2ACE
SCHEMBL6159996 0.88 GHSR (0.51) MEN1KMT2APKMFPR2ACE
SCHEMBL6161560 0.85 MEN1 (0.57) MEN1KMT2ACTSLCTSSCTSK
SCHEMBL6161139 0.85 MEN1 (0.57) MEN1KMT2ACTSLCTSSCTSK
SCHEMBL6161131 0.85 MEN1 (0.57) MEN1KMT2ACTSLCTSSCTSK
SCHEMBL6161758 0.85 MEN1 (0.57) MEN1KMT2ACTSLCTSSCTSK
SCHEMBL6164109 0.85 MEN1 (0.57) MEN1KMT2ACTSLCTSSCTSK
SCHEMBL6162094 0.81 MEN1 (0.53) MEN1KMT2ACTSLCTSSCTSK
SCHEMBL6162087 0.81 MEN1 (0.53) MEN1KMT2ACTSLCTSSCTSK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0828754-B1 DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE PFIZER (US) 2005-02-02 — — EP disclosed