Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PAM | P19021 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.31 |
| ▸ | RELA | Q04206 | 1/20 | 0.31 |
| ▸ | DAO | P14920 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6160152 | 1.00 | MAPT (0.43) | MAPTALDH1A1POLBHPGDGSTP1 | |
| SCHEMBL5252120 | 1.00 | MAPT (0.43) | MAPTALDH1A1POLBHPGDGSTP1 | |
| SCHEMBL22636046 | 0.70 | MEN1 (0.37) | LMNASMN1; SMN2MEN1KMT2AGRM5 | |
| SCHEMBL5924622 | 0.70 | SMN1; SMN2 (0.34) | LMNASMN1; SMN2MEN1KMT2AGRM5 | |
| SCHEMBL24311920 | 0.68 | SMN1; SMN2 (0.43) | ALDH1A1LMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL8051884 | 0.67 | ALDH1A1 (0.49) | MAPTALDH1A1POLBHPGDGSTP1 | |
| SCHEMBL6161927 | 0.67 | GSTP1 (0.38) | MAPTALDH1A1POLBHPGDGSTP1 | |
| SCHEMBL6161924 | 0.67 | GSTP1 (0.38) | MAPTALDH1A1POLBHPGDGSTP1 | |
| SCHEMBL7893034 | 0.65 | ABCB1 (0.38) | MEN1KMT2AGRM5 | |
| SCHEMBL9198436 | 0.61 | ALDH1A1 (0.56) | MAPTALDH1A1POLBHPGDGSTP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0828754-B1 | DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE | PFIZER (US) | 2005-02-02 | — | — | EP | disclosed |
| CN-1113895-C | Growth hormone secretagogues | PFIZER (US) | 2003-07-09 | — | — | CN | disclosed |
| US-5936089-A | PIPERIDINE DERIVATIVES; BONE DISORDERS; OBESITY; AGING; CACHEXIA ASSOCIATED WITH AIDS AND CANCER | PFIZER INC (US) | 1999-08-10 | — | — | US | disclosed |