Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 17/20 | 0.33 |
| ▸ | CASP1 | P29466 | 15/20 | 0.32 |
| ▸ | CASP7 | P55210 | 13/20 | 0.32 |
| ▸ | CASP8 | Q14790 | 13/20 | 0.32 |
| ▸ | CASP6 | P55212 | 11/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6200874 | 0.79 | CASP3 (0.35) | CASP3CASP1CASP8 | |
| SCHEMBL6157558 | 0.74 | KMT2A (0.48) | CASP1 | |
| SCHEMBL5831766 | 0.72 | KDM4E (0.35) | CASP3CASP1CASP7CASP8CASP6 | |
| SCHEMBL29317498 | 0.69 | SMN1; SMN2 (0.35) | CASP3CASP1CASP8 | |
| SCHEMBL3469761 | 0.68 | KMT2A (0.39) | CASP3CASP1CASP8 | |
| SCHEMBL644947 | 0.68 | KMT2A (0.39) | CASP3CASP1CASP8 | |
| SCHEMBL1490171 | 0.68 | KMT2A (0.39) | CASP3CASP1CASP8 | |
| SCHEMBL5496674 | 0.68 | CASP3 (0.50) | CASP3CASP1CASP7CASP8CASP6 | |
| SCHEMBL5496679 | 0.68 | CASP3 (0.50) | CASP3CASP1CASP7CASP8CASP6 | |
| SCHEMBL5491311 | 0.68 | CASP3 (0.50) | CASP3CASP1CASP7CASP8CASP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1082127-B1 | SUCCINAMIDE INHIBITORS OF INTERLEUKIN-1BETA CONVERTING ENZYME | WARNER LAMBERT CO (US) | 2005-06-22 | — | — | EP | disclosed |
| EP-1082127-A4 | SUCCINAMIDE INHIBITORS OF INTERLEUKIN-1$g(b) CONVERTING ENZYME | WARNER LAMBERT CO (US) | 2002-10-09 | — | — | EP | disclosed |
| EP-1082127-A1 | SUCCINAMIDE INHIBITORS OF INTERLEUKIN-1$g(b) CONVERTING ENZYME | WARNER-LAMBERT COMPANY (US) | 2001-03-14 | — | — | EP | disclosed |
| WO-1999056765-A1 | SUCCINAMIDE INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME | WARNER-LAMBERT COMPANY (US) | 1999-11-11 | — | — | WO | disclosed |