Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.45 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 2/20 | 0.40 |
| ▸ | BDKRB1 | P46663 | 6/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5785613 | 0.84 | KDM4E (0.47) | KMT2AHRH3 | |
| SCHEMBL4420793 | 0.83 | BDKRB1 (0.42) | F10BDKRB1HRH3 | |
| SCHEMBL5842753 | 0.76 | BDKRB1 (0.51) | F10BDKRB1 | |
| SCHEMBL4793955 | 0.74 | BDKRB1 (0.49) | SMN1; SMN2F10BDKRB1 | |
| SCHEMBL6160214 | 0.74 | SPHK1 (0.46) | SPHK1ITGB3ITGA2BNPC1MAPT | |
| SCHEMBL21101188 | 0.72 | CHKA (0.50) | ITGB3ITGA2BMAPTF10BDKRB1 | |
| SCHEMBL4718806 | 0.72 | BDKRB1 (0.52) | ITGB3ITGA2BBDKRB1 | |
| SCHEMBL5180328 | 0.71 | DNM1 (0.43) | SPHK1ITGB3ITGA2BF10HRH3 | |
| SCHEMBL5178486 | 0.71 | DNM1 (0.43) | SPHK1ITGB3ITGA2BF10HRH3 | |
| SCHEMBL786310 | 0.71 | CHKA (0.46) | ITGB3ITGA2BF10BDKRB1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1549622-A1 | SULFONYLBENZODIAZEPINONE ACETAMIDES AS BRADYKININ ANTAGONISTS | Elian Pharmaceuticals Inc. (US) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004033436-A1 | SULFONYLBENZODIAZEPINONE ACETAMIDES AS BRADYKININ ANTAGONISTS | ELAN PHARMACEUTICALS INC (US) | 2004-04-22 | — | — | WO | disclosed |