Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.55 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 4/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11451808 | 0.98 | PTPN1 (0.57) | PTPN1PTPN11MAPK8TSHRCYP3A4 | |
| SCHEMBL3084388 | 0.95 | L3MBTL1 (0.50) | PTPN1PTPN11MAPK8TSHRCYP3A4 | |
| SCHEMBL1671161 | 0.90 | KDM4E (0.52) | PTPN1MAPK8TSHRCYP3A4MAPK1 | |
| SCHEMBL1681179 | 0.86 | LMNA (0.61) | PTPN1TSHRCYP3A4TP53MAPK1 | |
| SCHEMBL123523 | 0.85 | L3MBTL1 (0.64) | TSHRMAPK1L3MBTL1LMNAALDH1A1 | |
| SCHEMBL19149220 | 0.84 | LMNA (0.64) | PTPN1TSHRCYP3A4TP53MAPK1 | |
| SCHEMBL9428921 | 0.84 | LMNA (0.50) | PTPN1PTPN11TSHRCYP3A4TP53 | |
| SCHEMBL19151006 | 0.84 | LMNA (0.64) | PTPN1TSHRCYP3A4TP53MAPK1 | |
| SCHEMBL6043383 | 0.84 | KDM4E (0.49) | PTPN1TSHRCYP3A4MAPK1L3MBTL1 | |
| SCHEMBL1505205 | 0.82 | KDM4E (0.50) | TSHRCYP3A4MAPK1L3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1492784-A2 | SUBSTITUTED 2,3-DIPHENYL PYRIDINES | Merck & Co., Inc. (US) | 2005-01-05 | — | — | EP | claimed |
| WO-2003082191-A2 | SUBSTITUTED 2,3-DIPHENYL PYRIDINES | MERCK & CO., INC. (US) | 2003-10-09 | — | — | WO | claimed |
| US-4181658-A | Certain nicotinamido-n-benzoic acid derivatives | HOECHST AKTIENGESELLSCHAFT (DE) | 1980-01-01 | — | — | US | disclosed |
| US-4157395-A | TREATMENT OF DIABETES | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-06-05 | — | — | US | disclosed |