Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ALOX5AP | P20292 | 5/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | ACSL1 | P33121 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.38 |
| ▸ | NTRK2 | Q16620 | 4/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6159451 | 0.85 | NPC1 (0.42) | NPC1GAARAB9ASMN1; SMN2ALOX5AP | |
| SCHEMBL7436191 | 0.79 | F2 (0.44) | NPC1GAARAB9ASMN1; SMN2ALOX5AP | |
| SCHEMBL7115169 | 0.79 | F2 (0.42) | RAB9AALOX5APHDAC1HDAC8ACSL1 | |
| SCHEMBL7120171 | 0.77 | HDAC1 (0.43) | RAB9AHDAC1HDAC8ACSL1F2 | |
| SCHEMBL6159720 | 0.77 | ITK (0.46) | NPC1GAARAB9ASMN1; SMN2HDAC1 | |
| SCHEMBL6157976 | 0.77 | NPC1 (0.59) | NPC1GAARAB9ASMN1; SMN2ALOX5AP | |
| SCHEMBL8031770 | 0.76 | F2 (0.54) | SMN1; SMN2ACSL1F2ALDH1A1 | |
| SCHEMBL8031773 | 0.74 | F2 (0.45) | SMN1; SMN2ACSL1F2ALDH1A1 | |
| SCHEMBL7437334 | 0.74 | F2 (0.41) | NPC1GAARAB9ASMN1; SMN2ALOX5AP | |
| SCHEMBL6486632 | 0.73 | F2 (0.50) | NPC1GAARAB9ASMN1; SMN2HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1237877-B1 | CARBOXAMIDE-SUBSTITUTED BENZIMIDAZOL DERIVATIVES, METHODS FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA (DE) | 2005-07-27 | — | — | EP | disclosed |
| US-6407130-B1 | ANTIALLERGENS, ANTIINFLAMMATORY AND ANTIARTHRITIC AGENTS; RESPIRATORY SYSTEM, GASTROINTESTINAL DISORDERS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-06-18 | — | — | US | disclosed |