Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCRL | Q16602 | 15/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.49 |
| ▸ | CCR5 | P51681 | 1/20 | 0.46 |
| ▸ | RAMP1 | O60894 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6160802 | 1.00 | CALCRL (0.51) | CALCRLCYP3A4CCR5RAMP1HSD11B1 | |
| SCHEMBL6162765 | 0.97 | CALCRL (0.51) | CALCRLCYP3A4CCR5RAMP1HSD11B1 | |
| SCHEMBL6162769 | 0.97 | CALCRL (0.51) | CALCRLCYP3A4CCR5RAMP1HSD11B1 | |
| SCHEMBL6161677 | 0.90 | CALCRL (0.57) | CALCRLCYP3A4CCR5RAMP1HSD11B1 | |
| SCHEMBL6162040 | 0.86 | CALCRL (0.52) | CALCRLCYP3A4CCR5RAMP1HSD11B1 | |
| SCHEMBL6162035 | 0.86 | CALCRL (0.52) | CALCRLCYP3A4CCR5RAMP1HSD11B1 | |
| SCHEMBL6163808 | 0.85 | CALCRL (0.51) | CALCRLCYP3A4CCR5RAMP1HSD11B1 | |
| SCHEMBL6163802 | 0.85 | CALCRL (0.51) | CALCRLCYP3A4CCR5RAMP1HSD11B1 | |
| SCHEMBL6163603 | 0.83 | CALCRL (0.59) | CALCRLCYP3A4RAMP1HSD11B1 | |
| SCHEMBL6161636 | 0.83 | CALCRL (0.59) | CALCRLCYP3A4RAMP1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0939632-B1 | NON-PEPTIDYL VASOPRESSIN V1a ANTAGONISTS | LILLY CO ELI (US) | 2005-10-05 | — | — | EP | disclosed |
| EP-0828754-B1 | DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE | PFIZER (US) | 2005-02-02 | — | — | EP | disclosed |
| US-6610680-B1 | Administering as adjuncts in heart failure or as antithrombotic agents, treatment of obsessive-compulsive disorder, aggressive disorders, depression and anxiety | ELI LILLY AND COMPANY | 2003-08-26 | — | — | US | disclosed |
| US-20020049187-A1 | Non-peptidyl vasopressin V1a antagonists | BRUNS ROBERT F (US) | 2002-04-25 | — | — | US | disclosed |
| US-6204260-B1 | 2-(AZETIDIN-2-ON-1-YL)ACETIC ACID DERIVATIVES | ELI LILLY AND COMPANY | 2001-03-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020049187-A1 | Non-peptidyl vasopressin V1a antagonists | AVPR1A, AVPR2, AVPR1B | CALCRL 124/4885CYP3A4 4049/4885CCR5 691/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.