Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCRL | Q16602 | 13/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.53 |
| ▸ | RAMP1 | O60894 | 1/20 | 0.50 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.50 |
| ▸ | PPARA | Q07869 | 1/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.48 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.48 |
| ▸ | CCR5 | P51681 | 1/20 | 0.48 |
| ▸ | CTSS | P25774 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6162040 | 0.92 | CALCRL (0.52) | CALCRLCYP3A4RAMP1HSD11B1CHRM2 | |
| SCHEMBL6162035 | 0.92 | CALCRL (0.52) | CALCRLCYP3A4RAMP1HSD11B1CHRM2 | |
| SCHEMBL6163808 | 0.91 | CALCRL (0.51) | CALCRLCYP3A4RAMP1HSD11B1CHRM2 | |
| SCHEMBL6163802 | 0.91 | CALCRL (0.51) | CALCRLCYP3A4RAMP1HSD11B1CHRM2 | |
| SCHEMBL6160795 | 0.90 | CALCRL (0.51) | CALCRLCYP3A4RAMP1HSD11B1CHRM2 | |
| SCHEMBL6160802 | 0.90 | CALCRL (0.51) | CALCRLCYP3A4RAMP1HSD11B1CHRM2 | |
| SCHEMBL8332468 | 0.90 | OPRM1 (0.52) | CALCRLCYP3A4RAMP1HSD11B1CCR5 | |
| SCHEMBL6162769 | 0.89 | CALCRL (0.51) | CALCRLCYP3A4RAMP1HSD11B1CCR5 | |
| SCHEMBL6162765 | 0.89 | CALCRL (0.51) | CALCRLCYP3A4RAMP1HSD11B1CCR5 | |
| SCHEMBL6165662 | 0.89 | CALCRL (0.55) | CALCRLCYP3A4RAMP1HSD11B1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0828754-B1 | DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE | PFIZER (US) | 2005-02-02 | — | — | EP | disclosed |
| US-5936089-A | PIPERIDINE DERIVATIVES; BONE DISORDERS; OBESITY; AGING; CACHEXIA ASSOCIATED WITH AIDS AND CANCER | PFIZER INC (US) | 1999-08-10 | — | — | US | disclosed |