Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.33 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8416889 | 0.85 | EDNRA (0.51) | EDNRAALDH1A1AGTR1AGTR2KDM4E | |
| SCHEMBL8784081 | 0.82 | MAPK1 (0.41) | EDNRAALDH1A1MAPK1NPC1KDM4E | |
| SCHEMBL6162876 | 0.81 | EDNRA (0.60) | EDNRAALDH1A1MAPK1MCHR1AGTR1 | |
| SCHEMBL6162886 | 0.79 | EDNRA (0.49) | EDNRAALDH1A1MAPK1NPC1RAB9A | |
| SCHEMBL8431746 | 0.78 | EDNRA (0.48) | EDNRAALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL8431316 | 0.77 | EDNRA (0.52) | EDNRAALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL7506559 | 0.77 | BRS3 (0.40) | EDNRAALDH1A1NPC1KDM4EHPGD | |
| SCHEMBL6588042 | 0.75 | BRS3 (0.40) | EDNRAALDH1A1NPC1KDM4EHPGD | |
| SCHEMBL8431751 | 0.74 | EDNRA (0.48) | EDNRAALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL6159406 | 0.73 | EDNRA (0.63) | EDNRAALDH1A1AGTR1AGTR2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863896-B1 | NOVEL IMIDAZOLE DERIVATIVES, METHOD FOR PREPARING SAME, PHARMACEUTICAL COMPOSITIONS AND USE OF SAID DERIVATIVES AS ENDOTHELIN ANTAGONISTS | AVENTIS PHARMA SA (FR) | 2005-02-09 | — | — | EP | disclosed |
| US-5986103-A | IMIDAZOLE SUBSTITUTED BENZENE AND REDUCTION OF ABNORMAL STIMULATION OF ENDOTHELIN RECEPTORS | HOECHST MARION ROUSSEL (FR) | 1999-11-16 | — | — | US | disclosed |
| EP-0863896-A1 | NOVEL IMIDAZOLE DERIVATIVES, METHOD FOR PREPARING SAME, RESULTING INTERMEDIATES, PHARMACEUTICAL COMPOSITIONS AND USE OF SAID DERIVATIVES AS ENDOTHELIN ANTAGONISTS | HOECHST MARION ROUSSEL (FR) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997017340-A1 | NOVEL IMIDAZOLE DERIVATIVES, METHOD FOR PREPARING SAME, RESULTING INTERMEDIATES, PHARMACEUTICAL COMPOSITIONS AND USE OF SAID DERIVATIVES AS ENDOTHELIN ANTAGONISTS | HOECHST MARION ROUSSEL (FR) | 1997-05-15 | — | — | WO | disclosed |