Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.36 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6160989 | 0.85 | EDNRA (0.46) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL6164112 | 0.79 | EDNRA (0.49) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL6159406 | 0.79 | EDNRA (0.63) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL8434286 | 0.78 | EDNRA (0.64) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL8784081 | 0.77 | MAPK1 (0.41) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL6160979 | 0.77 | EDNRA (0.63) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL6588042 | 0.76 | BRS3 (0.40) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL7506559 | 0.76 | BRS3 (0.40) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL8431316 | 0.76 | EDNRA (0.52) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL6159408 | 0.76 | EDNRA (0.52) | EDNRAKDM4EALDH1A1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5986103-A | IMIDAZOLE SUBSTITUTED BENZENE AND REDUCTION OF ABNORMAL STIMULATION OF ENDOTHELIN RECEPTORS | HOECHST MARION ROUSSEL (FR) | 1999-11-16 | — | — | US | disclosed |