SCHEMBL6161112

SCHEMBL6161112

COc1ccccc1C1CNCCN1CCCCC12CCCc3c(C(C)=O)ccc(c31)NC2=O

nearest known ligand 0.55

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
HTR7 P34969 20/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6158345 0.94 HTR7 (0.54) HTR7
SCHEMBL6157638 0.94 HTR7 (0.49) HTR7
SCHEMBL6159599 0.92 HTR7 (0.58) HTR7
SCHEMBL6159186 0.91 HTR7 (0.52) HTR7
SCHEMBL6159486 0.90 HTR7 (0.53) HTR7
SCHEMBL6157015 0.89 HTR7 (0.53) HTR7
SCHEMBL6157355 0.74 HTR7 (0.61) HTR7
SCHEMBL6159301 0.71 HTR7 (1.00) HTR7
SCHEMBL9527372 0.69 HTR2C (0.46)
SCHEMBL6160438 0.68 HTR7 (0.73) HTR7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0937715-B1 TETRAHYDROBENZINDOLE COMPOUNDS MEIJI SEIKA KAISHA (JP) 2005-06-01 EP disclosed
US-6355642-B1 PSYCHOLOGICAL DISORDERS AND BRAIN DISORDERS MEIJI SEIKA KAISHA, LTD. (JP) 2002-03-12 US disclosed
EP-0937715-A1 TETRAHYDROBENZINDOLE COMPOUNDS MEIJI SEIKA KAISHA LTD. (JP) 1999-08-25 EP disclosed