Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 7/20 | 0.46 |
| ▸ | HTR2A | P28223 | 5/20 | 0.46 |
| ▸ | HTR2B | P41595 | 5/20 | 0.46 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.38 |
| ▸ | HTR3B | O95264 | 1/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.38 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5915126 | 0.85 | DRD2 (0.51) | HTR2CHTR2AHTR2BDRD2HTR3E | |
| SCHEMBL4125113 | 0.80 | HTR2C (0.39) | HTR2CHTR2AHTR2BDRD2SIGMAR1 | |
| SCHEMBL8757950 | 0.78 | TAAR1 (0.41) | HTR2CHTR2AHTR2BTAAR1 | |
| SCHEMBL1074633 | 0.78 | HTR2C (0.47) | HTR2CHTR2AHTR2BDRD2 | |
| SCHEMBL8406171 | 0.77 | HTR2C (0.43) | HTR2CHTR2AHTR2BDRD2ADRB1 | |
| SCHEMBL8017476 | 0.76 | HTR2C (0.41) | HTR2CHTR2AHTR2BDRD2HTR3E | |
| SCHEMBL5323955 | 0.75 | HSD17B10 (0.46) | HTR2CHTR2BDRD2HTR3EHTR3B | |
| SCHEMBL4969817 | 0.75 | HTR2C (0.35) | HTR2CHTR2AHTR2BDRD2 | |
| SCHEMBL8422421 | 0.75 | HTR2C (0.43) | HTR2CHTR2AHTR2BCHRNA7CYP2D6 | |
| SCHEMBL8055769 | 0.75 | HRH1 (0.56) | HTR2CHTR2AHTR2BDRD2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0372305-B1 | PIPERAZINYLALKYL-3(2H)-PYRIDAZINONES, METHOD FOR THEIR PREPARATION AND THEIR USE AS ANTIHYPERTENSIVE AGENTS | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1993-08-04 | — | — | EP | disclosed |
| US-5034391-A | Piperazinylalkyl-3(2H)-pyridazinones and the use thereof as agents lowering blood pressure | CL PHARMA AKTIENGESELLSCHAFT (AT) | 1991-07-23 | — | — | US | disclosed |
| EP-0286263-B1 | PSYCHOTROPIC POLYCYCLIC IMIDES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-05-15 | — | — | EP | disclosed |
| US-4939137-A | Ring-fused thienopyrimidinedione derivatives | ORTHO PHARMACEUTICAL CORPORATION (US) | 1990-07-03 | — | — | US | disclosed |
| EP-0372305-A1 | Piperazinylalkyl-3(2H)-pyridazinones, method for their preparation and their use as antihypertensive agents | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1990-06-13 | — | — | EP | disclosed |
| US-4824999-A | INTERMEDIATES FOR ANTIPSYCHOTIC AND ANXIOLYTIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-04-25 | — | — | US | disclosed |
| US-4797488-A | N-((4-(PHENYL OR HETEROCYCLIC)PIPERAZIN-1-YL)ALKYL)-1,5-METHANOCYCLOPENT(D)AZEPINE-2,4 -DIONES; ANXIOLYTIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-01-10 | — | — | US | disclosed |
| EP-0286263-A1 | Psychotropic polycyclic imides | AMERICAN HOME PRODUCTS CORPORATION (US) | 1988-10-12 | — | — | EP | disclosed |
| WO-1988007529-A1 | PSYCHOTROPIC POLYCYCLIC IMIDES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1988-10-06 | — | — | WO | disclosed |