Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | MMP3 | P08254 | 1/20 | 0.50 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.48 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1003503 | 0.85 | DRD2 (0.73) | DRD2SLC18A3CARM1PRMT6 | |
| SCHEMBL12668153 | 0.82 | DRD2 (0.77) | DRD2HRH3KDM4EALDH1A1 | |
| SCHEMBL12319791 | 0.82 | DRD2 (0.60) | DRD2HRH3MMP3SLC18A3SLC6A4 | |
| SCHEMBL7469402 | 0.82 | HRH3 (0.60) | DRD2HRH3MMP3SLC18A3CARM1 | |
| SCHEMBL27477245 | 0.81 | SLC18A3 (0.57) | DRD2HRH3MMP3SLC18A3 | |
| SCHEMBL7474765 | 0.81 | HRH3 (0.52) | DRD2HRH3MMP3SLC18A3 | |
| SCHEMBL3970721 | 0.79 | KDM1A (0.57) | HRH3MMP3SLC18A3SLC6A4 | |
| SCHEMBL19322267 | 0.79 | KDM1A (0.57) | HRH3MMP3SLC18A3SLC6A4 | |
| SCHEMBL9912191 | 0.79 | DRD2 (0.65) | DRD2SLC18A3CARM1PRMT6 | |
| SCHEMBL12041706 | 0.79 | S1PR1 (0.69) | DRD2HRH3ALDH1A1MMP3SLC18A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0755923-B1 | Ameliorant or remedy for symptoms caused by Ischemic diseases and Phenylpiperidine compounds useful therefor | DAIICHI SUNTORY PHARMA CO LTD (JP) | 2005-05-04 | — | — | EP | disclosed |
| US-6469010-B1 | COMPOSITION ALSO FOR ALLEVIATION OR TREATMENT OF SYMPTOMS DERIVED FROM SEIZURES, EPILEPSY AND MIGRAINE HEADACHES, AND SUPPRESSION OF CALCIUM ION OVERLOAD | SUNTORY LIMITED (JP) | 2002-10-22 | — | — | US | disclosed |
| US-6048876-A | ANTICONVULSANTS; ANTIEPILEPIC AGENT | SUNTORY LIMITED (JP) | 2000-04-11 | — | — | US | disclosed |
| EP-0755923-A1 | AMELIORANT OR REMEDY FOR SYMPTOMS CAUSED BY ISCHEMIC DISEASES AND COMPOUNDS USEFUL THEREFOR | SUNTORY LIMITED (JP) | 1997-01-29 | — | — | EP | disclosed |