Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.52 |
| ▸ | BTK | Q06187 | 2/20 | 0.48 |
| ▸ | MMP3 | P08254 | 1/20 | 0.47 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.44 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14328412 | 0.86 | SLC18A3 (0.57) | KCNA3DRD2SLC18A3 | |
| SCHEMBL6161283 | 0.81 | DRD2 (0.55) | HRH3MMP3DRD2SLC18A3 | |
| SCHEMBL7469402 | 0.78 | HRH3 (0.60) | HRH3MMP3DRD2SLC18A3 | |
| SCHEMBL16994793 | 0.77 | TLR9 (0.46) | DRD2SLC18A3 | |
| SCHEMBL6160199 | 0.77 | HRH3 (0.49) | HRH3MMP3DRD2 | |
| SCHEMBL6160208 | 0.77 | HRH3 (0.49) | HRH3MMP3DRD2 | |
| SCHEMBL1307520 | 0.76 | HRH3 (0.58) | HRH3DRD2 | |
| SCHEMBL19322267 | 0.76 | KDM1A (0.57) | HRH3MMP3SLC18A3 | |
| SCHEMBL3970721 | 0.76 | KDM1A (0.57) | HRH3MMP3SLC18A3 | |
| SCHEMBL12041706 | 0.75 | S1PR1 (0.69) | HRH3MMP3DRD2SLC18A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0757986-B1 | Arylpiperidine and arylpiperazine derivatives and drugs containing the same | SUNTORY LTD (JP) | 2002-06-12 | — | — | EP | disclosed |
| US-5723475-A | Arylpiperidine and arylpiperazine derivatives and medicament containing the same | SUNTORY LIMITED (JP) | 1998-03-03 | — | — | US | disclosed |
| EP-0757986-A1 | ARYLPIPERIDINE AND ARYLPIPERAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME | SUNTORY LIMITED (JP) | 1997-02-12 | — | — | EP | disclosed |